Genotype and allele frequencies of the Met326Ile p85α regulatory subunit of phosphatidyl inositol 3 kinase (PIK3R1) polymorphism resulting from the 1020-G/A base substitution in 202 patients with Alzheimer's disease (AD) and 170 age matched controls for the total population and after stratification by sex. Results from logistic regression analysis are also presented
| Total | Men | Women | ||||
|---|---|---|---|---|---|---|
| PIK3R1 | AD (n=202) | Controls (n=170) | AD (n=44) | Controls (n=73) | AD (n=158) | Controls (n=97) |
| CI, 95% confidence interval; OR, odds ratio. *p<0.05. Data are number (%). | ||||||
| Genotypes | ||||||
| GG | 151 (0.75) | 112 (0.66) | 32 (0.73) | 53 (0.72) | 119 (0.75) | 59 (0.61) |
| GA + | 48 (0.24) | 54 (0.32) | 11 (0.25) | 18 (0.25) | 37 (0.23) | 36 (0.37) |
| AA | 3 (0.01) | 4 (0.02) | 1 (0.02) | 2 (0.03) | 2 (0.01) | 2 (0.02) |
| OR 1.60, CI 0.98 to 2.62, p=0.06 | OR 0.83, CI 0.34 to 2.03, p=0.68 | OR 2.09, CI 1.17 to 3.74, p=0.01* | ||||
| Alleles | ||||||
| G | 350 (0.87) | 278 (0.82) | 75 (0.84) | 124 (0.85) | 275 (0.87) | 154 (0.79) |
| A | 54 (0.13) | 62 (0.18) | 13 (0.16) | 22 (0.15) | 41 (0.13) | 40 (0.21) |
| OR 1.55, CI 0.99 to 2.43, p=0.05 | OR 0.65, CI 0.16 to 2.79, p=0.56 | OR 1.99, CI 1.17 to 3.40, p=0.01* | ||||