Table 1

Clinical information and HLA-DRB1 alleles in 12 cases of B19 meningoencephalitis

NoSexAge (gest)Symptoms and signs†EEG resultBrain scan (CT/MR)DeathSequelaeHLA-DRB1 alleles
The twin of case 11 was born with “cerebral palsy” consisting of right sided hemiplegia, deafness in the right ear, and poor control of the right eye. This baby also had seizures and surfactant deficient lung disease.
†Published previously.1
ASD, atrial septal defect; cALL, common acute lymphoblastic leukaemia; d, day; DIC, disseminated intravascular coagulation; F, female; gest, gestation; HLH, haemophagocytic lymphohistiocytosis (diagnosed both antemortem (bone marrow) and postmortem); m, month; M, male; N, no; ND, not determined; NEC, necrotising enterocolitis, PDA, patent ductus arteriosus; URTI, upper respiratory tract infection; USS, ultrasound scan; VSD, ventricular septal defect; wk, week; y, year; Y, yes.
1M2 mMeningitis, pyrexia, URTI, anaemia (Hb 8.8 g/dl)NDNN*04/*14
2M2 mEncephalitis, conjunctivitis, URTINormalMR, normalNN*13/*15
3M6 mMeningitis, pyrexia, hepatosplenomegaly, cervical lymphadenopathy, pancytopenia, anaemia (Hb 8.5 g/dl), prolonged clotting time, hepatitis, HLHNDY
4M2 y, 1 mEncephalitis, pyrexia, cALLEncephalopathicMR, abnormalNY*04
5F2 y, 3 mEncephalitis, ataxia, anaemia (Hb 10.9 g/dl), hepatitisEncephalopathicCT, normalNN*04/*07
6F6 y, 4 mEncephalitis, thrombocytopenia, hepatitis, DIC, acute renal failure, multiple organ failure, Cockayne syndromeSilenceY
7M9 yEncephalitis, thrombocytopenia, anaemia (Hb 10.7 g/dl), cervical lymphadenopathyEncephalopathicMR, abnormalNY
8F13 yEncephalitis, liver failure, Crigler-Najjar syndromeNDNDND
9M13 yEncephalitis, hemiparesis, ataxiaPost-ictal EEG: slow on leftMR+CT, normalNN
10F15 yEncephalitisEncephalopathicCT, abnormalNY*03/*04
11F1 d (23 wk)Encephalitis, NEC, PDA, hepatitis, surfactant deficiency, osteopenia of immaturity, valgus leg deformity at age 1 yNDNY
12F1 d (36 wk)Encephalitis, VSD, ASD, PDA, poor respiratory drive, obstructive jaundice, persistent anaemia, 47XXXND[USS, cysts on choroid plexus]Y