Muscle pathology in patients with anti-SRP antibodies
Patient No | |||||||
---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | |
NA, tissue type not present for evaluation in biopsy; +, present in biopsy; −, not present in biopsy. | |||||||
Time from disease onset to muscle biopsy (months) | 5 | 36 | 3 | 8 | 10 | 3 | 2 |
Pathological features | |||||||
Lymphocytic inflammation | |||||||
Perimysial | − | − | − | − | − | − | − |
Endomysial | ± | − | + | − | − | − | − |
Perivascular | + | − | − | − | − | − | − |
Muscle fibre size | |||||||
Variation | + | NA | + | + | + | + | + |
Bimodal | + | NA | + | + | + | + | + |
Hypertrophy | + | NA | + | + | + | + | − |
Hypercontracted fibres | + | NA | − | + | − | − | − |
Grouped small round fibres | + | NA | + | + | + | + | + |
Perifascicular atrophy | − | NA | − | − | − | − | − |
Muscle fibre pathology | |||||||
Necrosis | |||||||
Scattered | + | NA | + | + | + | + | + |
Regional (large groups) | − | NA | − | − | − | − | − |
Regeneration | + | NA | + | + | + | + | + |
Coarse internal architecture | + | NA | + | + | + | + | + |
Immature (2C) fibres | + | NA | + | + | − | + | + |
Mitochondrial changes | − | NA | − | − | − | − | − |
C5b-9 deposition | ± | NA | − | − | − | − | − |
Connective tissue features | |||||||
Endomysial | |||||||
Increased | + | NA | + | + | + | + | + |
Acid phosphatase+/CD68+ cells | + | NA | + | + | + | + | + |
Perimysial | |||||||
Fragmentation | − | − | + | − | − | − | − |
Alkaline phosphatase staining | + | − | + | − | + | − | − |
Acid phosphatase+/CD68+ cells | − | − | + | − | − | + | − |
Vessels | |||||||
Capillaries | |||||||
Reduced number | + | NA | + | − | + | − | + |
Enlarged size | + | NA | + | + | + | + | + |
C5b-9 deposition | + | + | + | + | + | + | + |