Measurable synergistic effects between unfavourable genotypes and clinical risk factors on the incidence of ischaemic stroke
| Clinical risk factors alone or in combination with synergistic unfavourable genotypes | OR (95% CI) |
|---|---|
| OR, odds ratios; CI, confidence interval. | |
| §p<0.003; ***p<0.001; †p<0.0001. | |
| Hypertension | 3.6 (6.3 to 1.8)§ |
| Hypertension+Leiden V allele | 10.8 (33.1 to 3.5)† |
| Hypertension+APOE 4 allele | 15.6 (52.2 to 3.8)† |
| Diabetes mellitus | 4.1 (8.6 to 2.1)† |
| Diabetes mellitus+Leiden V allele | 8.3 (19.6 to 3.2)† |
| Diabetes mellitus+APOE 4 allele | 18.8 (62.6 to 4.4)† |
| Smoking | 2.3 (4 to 1.4)*** |
| Smoking+ACE D/D | 8.5 (19.8 to 3.4)† |
| Smoking+MTHFR677TT | 6.3 (13.7 to 2.8)† |
| Smoking+APOE 4 allele | 16.4 (54.4 to 4.1)† |
| Drinking | 2.9 (5.4 to 1.4)† |
| Drinking+ACE D/D | 12.2 (36.4 to 3.7)† |
| Drinking+MTHFR 677TT | 9.1 (25.2 to 3.4)† |
| Drinking+APOE allele | 11.8 (36.2 to 3.5)† |