Mean (SD) values (range) of several serum S100B values, of the S100B area under the curve (AUC), and of the S100B peak value in n=23 patients with confirmed proximal middle cerebral artery occlusion (MCA/M1)
| Early (<6 hrs) MCA/M1 recanalisation | |||
|---|---|---|---|
| S100B measurement | Observed (n=7) | Not observed (n=16) | P* |
| *According to the modified Bonferroni correction (α adjustement), we used a p value of <0.0056 (0.05/9=0.0056) to indicate significant findings. †Occurrence of the S100B peak after stroke onset was not significantly different between groups (58.2 (25.7) h for recanalisation observed versus 77.8 (28.7) h for recanalisation not observed, p=0.19, Mann-Whitney U test). | |||
| Baseline (μg/l) | 0.10 (0.03) (0.05–0.14) | 0.15 (0.08) (0.06–0.36) | 0.089 |
| 8 h (μg/l) | 0.11 (0.02) (0.09–0.14) | 0.28 (0.38) (0.07–1.53) | 0.076 |
| 16 h (μg/l) | 0.19 (0.18) (0.07–0.58) | 1.20 (1.47) (0.07–4.71) | 0.039 |
| 24 h (μg/l) | 0.27 (0.34) (0.08–1.02) | 1.61 (1.59) (0.07–5.09) | 0.010 |
| 48 h (μg/l) | 0.37 (0.63) (0.07–1.79) | 3.49 (2.12) (0.71–6.84) | <0.001* |
| 72 h (μg/l) | 0.30 (0.40) (0.08–1.19) | 3.76 (2.43) (0.60–7.23) | <0.001* |
| 96 h (μg/l) | 0.24 (0.25) (0.09–0.81) | 4.42 (3.18) (0.50–9.46) | <0.001* |
| AUC (μg/l/h) | 22.2 (40.1) (1.3–114.2) | 406.8 (284.4) (45.9–911.1) | <0.001* |
| Peak (μg/l)† | 0.58 (0.99) (0.10–2.82) | 5.44 (3.61) (0.73–12.20) | <0.001* |