Table 1

Within-group activations (SPM99 random effects)

ContrastRegionBAxyzNo of voxelsz Valuep Value (uncorrected)
BA, Brodmann area; NvF, novel v fixation; NvR, novel v repeated; RvF, repeated v fixation.
Young controls
NvFMiddle/inferior frontal gyrusBA 9/46542724764.040.00003
Middle frontal gyrusBA 6−426521894.640.000002
Inferior frontal gyrusBA 47−2720−9113.420.0003
Medial frontal gyrusBA 6−62043584.620.000002
Anterior cingulateBA 33−6719183.930.00004
Caudate−18−217303.870.00005
Thalamus18−1715204.210.00001
Hippocampal formation−24−24−111044.660.000002
Hippocampal formation21−30−91104.720.000001
Extrastriate/fusiform gyrusBA 20−39−48−253304.40.000005
Extrastriate/fusiform gyrusBA 2042−48−281054.120.00002
RvFFusiform gyrusBA 3742−48−25123.380.0004
Extrastriate/fusiform gyrusBA 19−45−62−22884.50.000003
Extrastriate/fusiform gyrusBA 1939−65−25183.750.00009
Extrastriate/lingual gyrusBA 18−21−85−6314.230.00001
NvROrbital frontalBA 11/472731−14394.180.00001
Medial frontal gyrusBA 6/8−62043924.260.00001
Inferior frontal gyrusBA 9421624554.110.00002
Inferior frontal gyrusBA 9−4210221173.910.00005
Anterior cingulateBA 3361019133.660.0001
Middle frontal gyrusBA 6−40655164.710.000001
Hippocampal formationBA 35−21−27−111405.010.0000003
Hippocampal formationBA 3524−30−11994.940.0000004
Extrastriate/fusiform gyrusBA 2042−48−281034.190.00001
Extrastriate/fusiform gyrusBA 20−39−48−282584.170.00002
Angular gyrusBA 3939−6931104.020.00003
Elderly controls
NvFInferior frontal gyrusBA 4551389533.860.00006
Inferior frontal gyrusBA 47−3629−6123.420.0003
Inferior frontal gyrusBA 45−542113173.620.0001
Inferior frontal gyrusBA 9531033563.750.00009
Anterior cingulateBA 33−31019134.250.00001
Putamen−21−89184.060.00002
Hippocampal formation−21−27−14844.30.000008
Hippocampal formation21−24−14303.980.00004
Extrastriate/fusiform gyrusBA 3754−56−17654.550.000003
Extrastriate/fusiform gyrusBA 37−45−57−223455.230.00000009
Superior parietal lobuleBA 7−27−5944553.570.0002
RvFInferior frontal gyrusBA 44/45−423012363.80.00007
Hippocampal formation27−18−14384.180.00001
Inferior parietal lobuleBA 40−27−5936113.430.0003
Inferior parietal lobuleBA 4042−5047153.680.0001
Superior parietal lobuleBA 7−33−5052183.560.0002
Superior parietal lobuleBA 7−30−7442123.670.0001
Extrastriate/fusiform gyrusBA 37−45−54−23944.470.000004
Extrastriate/fusiform gyrusBA 3748−54−20294.120.00002
Middle temporal gyrusBA 19−33−7818233.510.0002
NvRAnterior cingulateBA 33−310221740.00003
Putamen−21−119163.530.0002
Hippocampal formationBA 28−27−24−6584.360.000006
Hippocampal formationBA 2815−24−14173.580.0002
Extrastriate/fusiform gyrusBA 37−39−45−262514.610.000002
Mild Alzheimer’s disease
NvFInferior frontal gyrusBA 9−481624753.710.0001
Inferior frontal gyrusBA 9481332213.660.0001
Hippocampal formationBA 2821−27−9193.650.0001
Precuneus/superior parietal lobuleBA 718−5647744.380.000006
Superior parietal lobuleBA 7−33−5947213.580.0002
Extrastriate/fusiform gyrusBA 37−27−45−18503.820.00007
Extrastriate/fusiform gyrusBA 1915−67−9233.920.0004
RvFNo significant clusters found
NvRFusiform gyrusBA 379−44−8103.50.0002