Table 2

Between-group differences (SPM99 random effects)

Contrast	Region	BA	x	y	z	No of voxels	z Value	p Value (uncorrected)
BA, Brodmann area; NvF, novel v fixation; NvR, novel v repeated; RvF, repeated v fixation.
Young control > elderly control
NvF	Superior frontal gyrus	BA 10	−18	53	17	80	3.49	0.0002
	Superior frontal gyrus	BA 10	18	62	24	12	2.43	0.008
	Inferior frontal gyrus	BA 46	−45	47	3	23	3.2	0.001
	Extrastriate/lingual gyrus	BA 18	−9	−64	6	25	2.76	0.003
	Extrastriate/lingual gyrus	BA 19	33	−67	−4	91	3.29	0.001
RvF	No significant clusters
NvR	Inferior frontal gyrus	BA 46	−45	47	3	79	3.35	0.0004
	Middle frontal gyrus	BA 9	−42	13	24	12	2.72	0.003
	Caudate		21	29	4	13	2.74	0.003
	Caudate		9	12	−1	17	3.04	0.001
	Thalamus		0	−18	−4	159	3.1	0.001
	Hippocampal formation		30	−24	−11	62	3.39	0.0003
	Extrastriate/lingual gyrus	BA 18	−15	−64	3	464	3.63	0.0001
	Extrastriate/lingual gyrus	BA 18	6	−70	−7	188	3.09	0.001
Elderly control > young control
NvF	Anterior cingulate	BA 24	−9	30	12	50	3.55	0.0002
	Cingulate gyrus	BA 24	12	13	32	46	2.78	0.003
	Cingulate gyrus	BA 24	3	−4	39	41	3.22	0.001
	Inferior frontal gyrus	BA 9	24	10	33	24	3.1	0.001
	Inferior frontal gyrus	BA 9	60	7	22	123	3.13	0.001
	Middle frontal gyrus	BA 6	24	5	47	42	3.2	0.001
	Superior temporal gyrus	BA 38	56	14	−16	14	3.18	0.001
	Superior temporal gyrus	BA 38	−45	−21	−7	51	2.93	0.002
	Inferior parietal lobule	BA 40	−50	−22	29	160	3.3	0.0005
	Inferior parietal lobule	BA 40	42	−36	29	175	3.45	0.0003
	Superior parietal lobule	BA 7	18	−65	50	63	3.47	0.0003
	Superior parietal lobule	BA 7	−18	−71	31	181	3.37	0.0004
RvF	Middle frontal gyrus	BA 11	−30	31	−19	102	3.51	0.0002
	Inferior frontal gyrus	BA 47	36	29	−6	91	3.5	0.0002
	Inferior frontal gyrus	BA 9	24	10	33	150	3.87	0.0006
	Inferior frontal gyrus	BA 44	53	6	8	20	2.77	0.003
	Superior frontal gyrus	BA 8	−30	14	49	782	4.16	0.0002
	Thalamus		0	9	2	187	3.76	0.0008
	Hippocampal formation		27	−18	−14	24	2.8	0.003
	Cingulate gyrus	BA 31	−12	−27	43	20	2.86	0.002
	Fusiform gyrus	BA 20	45	−30	−14	44	3.12	0.001
	Fusiform gyrus	BA 20	33	−39	−13	16	2.71	0.003
	Middle temporal gyrus	BA 21	−50	−47	2	56	4.1	0.0002
	Superior parietal lobule	BA 7	−33	−50	49	1459	3.95	0.0004
NvR	Superior temporal gyrus	BA 6	−48	−3	6	15	2.58	0.005
	Postcentral gyrus	BA 3	60	−11	23	14	2.54	0.006
Elderly control > Alzheimer’s disease
NvF	Inferior frontal gyrus	BA 45	54	36	9	12	2.93	0.002
	Hippocampal formation		−30	−24	−4	11	2.78	0.003
	Hippocampal formation		12	−33	−13	63	2.99	0.001
	Superior parietal lobule	BA 7	−21	−60	42	12	2.57	0.005
RvF	Middle frontal gyrus	BA 11	27	42	−13	58	2.75	0.003
	Middle frontal gyrus	BA 6	−30	14	46	34	2.88	0.002
	Inferior frontal gyrus	BA 47	−18	37	−9	13	2.9	0.002
	Anterior cingulate	BA 24	−12	32	−1	15	3.03	0.001
	Putamen		24	6	5	60	2.71	0.003
	Hippocampal formation		27	−18	−14	10	3.09	0.001
	Hippocampal formation		−33	−27	−19	18	3.08	0.001
	Middle temporal gyrus	BA 39	36	−54	30	27	2.99	0.001
	Middle temporal gyrus	BA 39	−36	−75	23	166	3.87	0.0001
	Middle occipital gyrus	BA 19	30	−70	9	46	2.97	0.001
NvR	Hippocampal formation		15	−24	−16	24	2.86	0.002
Alzheimer’s disease > elderly control
NvF	Superior frontal gyrus	BA 9	−24	48	28	50	3.27	0.0001
	Middle temporal gyrus	BA 21	−42	−15	−9	10	2.72	0.003
	Superior temporal gyrus	BA 41	56	−25	10	20	2.77	0.003
	Posterior cingulate	BA 29	12	−37	21	18	3.17	0.001
	Precuneus	BA 31	9	−62	34	108	3.65	0.0001
	Precuneus	BA 31	−15	−69	28	57	3.46	0.0003
RvF	Superior frontal gyrus	BA 6	−9	26	57	10	3.9	0.00005
NvR	Superior frontal gyrus	BA 9	−27	48	28	35	3.48	0.0002
	Superior frontal gyrus	BA 9	−15	40	37	11	2.54	0.006
NvR	Cingulate	BA 10	−21	35	1	189	3.3	0.0005
	Middle temporal gyrus	BA 21	50	−4	−12	20	2.78	0.003
	Middle temporal gyrus	BA 21	−48	−9	−15	11	2.81	0.002
	Precuneus/posterior cingulate	BA 31	12	−57	33	443	3.6	0.0002
	Fusiform gyrus	BA 36	−36	−27	−19	22	2.99	0.001
	Precuneus	BA 31	−15	−66	28	83	3.35	0.0004
	Extrastriate/fusiform gyrus	BA 18	−21	−76	−4	31	2.89	0.002