Memory and changes in total cholesterol or low density lipoprotein cholesterol concentrations*
| β | Probability | Memory score† | ||||
|---|---|---|---|---|---|---|
| Decliners | Non-decliners | Difference Points | Difference z score | |||
| *β and probability values are based on multiple regression analyses with the memory score as the dependent variable and the change in total cholesterol level or low density lipoprotein cholesterol as the independent variable. Analyses were adjusted for control variables, as described in the text. The three year change was calculated as the difference between years 7+8 and years 4+5 lipid values; six year change was calculated as the difference between years 7+8 and years 1+2 values. | ||||||
| †Memory scores represent adjusted mean values. Decliners refers to women whose total cholesterol or low density lipoprotein cholesterol levels declined, and non-decliners refers to women whose levels did not decline. Differences between decliners and non-decliners were not evaluated for six year changes in total cholesterol and low density lipoprotein cholesterol, because six year changes were not significantly associated with memory. | ||||||
| §In analysis of covariance, F = 4.14, p = 0.04. | ||||||
| ‡In analysis of covariance, F = 9.22, p = 0.002. | ||||||
| n = number of women in each group. | ||||||
| Total cholesterol | ||||||
| three year | 0.891 | 0.01 | 28.8 | 29.8 | 1.0§ | 0.24 |
| change | (n = 131) | (n = 161) | ||||
| six year change | 0.370 | 0.3 | – | – | – | – |
| Low density lipoprotein cholesterol | ||||||
| three year | 1.224 | 0.003 | 28.3 | 30.0 | 1.7‡ | 0.39 |
| change | (n = 97) | (n = 187) | ||||
| six year change | 0.743 | 0.07 | – | – | – | – |