CSF Hypocretin-1 in patients with Kleine-Levin syndrome
| Subjects | Centre | Age | Sex | Age of onset | Cognitive alteration | Hyper-phagia | Hyper-sexuality | Triggering factor | Duration of episode | Number of episodes | HLA DQB1* | Hypo-1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Centre 1: Montpellier, France; Centre 3: Paris, France | ||||||||||||
| Duration of episode = extreme values, in days | ||||||||||||
| na, not available | ||||||||||||
| Hypo-1, level of hypocretin-1 in the CSF (pg/ml) during asymptomatic periods except for patient 4, who had 221 pg/ml during asymptomatic periods and 111 pg/ml during symptomatic episodes | ||||||||||||
| 1 | 3 | 15 | M | 13 | + | − | + | + | 10–20 | 5 | 0301/0301 | 897 |
| 2 | 3 | 16 | F | 15 | + | + | − | − | 1–10 | 5 | 0301/0302 | 453 |
| 3 | 1 | 24 | F | 16 | + | − | − | − | 4–12 | 8 | na | 268 |
| 4 | 1 | 21 | M | 20 | + | + | + | + | 14–16 | 2 | 0201/05 | 221–111 |