CSF Hypocretin-1 in various neurological conditions
| Diagnosis | No | Centre | Sex | Age | Protein | Hypo-1 |
|---|---|---|---|---|---|---|
| Centre 1: Montpellier, France; Centre 2: Zurich, Switzerland | ||||||
| Protein = CSF protein expressed in g/ml | ||||||
| Hypo-1 = mean (SD) (range) level of hypocretin-1 in the CSF (pg/ml) | ||||||
| *CIDP, Chronic inflammatory demyelinating polyneuropathy; CNS, central nervous system | ||||||
| Neurodegenerative disease | ||||||
| Alzheimer’s disease | 8 | 1,2 | 2M, 6F | 70 (9.04) | 0.50 (0.16) | 483.87 (85.68) (356–577) |
| Parkinson’s disease | 3 | 2 | 1M, 2F | 71 (13) | 0.38 (0.11) | 279.67 (58.01) (221–337) |
| Motor neurone disease | 4 | 1,2 | 2M, 2F | 67 (12.06) | 0.31 (0.08) | 462.75 (58.53) (392–535) |
| Spastic paraplegia | 3 | 1,2 | 1M, 2F | 46.67 (20.13) | 0.39 (0.04) | 480.67 (74.78) (397–541) |
| Demyelinating diseases of CNS | ||||||
| Multiple sclerosis | 14 | 1,2 | 6M, 8F | 30.21 (10.21) | 0.43 (0.10) | 489.93 (244.56) (282–1280) |
| Devic disease | 1 | 1 | F | 49 | 0.41 | 874 |
| Inflammatory bowel disease | 1 | 1 | F | 45 | 0.27 | 310 |
| Peripheral neuropathies | ||||||
| Guillain-Barré syndrome | 2 | 1,2 | 2F | 21.5 (6.36) | 1.45 (1.2) | 980.5 (193.04) (844–1117) |
| CIDP* | 1 | 1 | M | 60 | 1.77 | 1333 |
| Diabetic polyneuropathy | 2 | 1 | M, F | 54.5 (4.95) | 0.79 (0.51) | 493.5 (4.95) (490–497) |
| Toxic polyneuropathy | 1 | 1 | M | 57 | 0.48 | 427 |
| Idiopathic polyneuropathy | 3 | 1,2 | 3F | 55 (5.57) | 0.5 (0.21) | 850.33 (285.67) (623–1171) |
| Vascular disease | ||||||
| Stroke | 6 | 1 | 3M, 3F | 65.67 (7.99) | 0.33 (0.08) | 617.00 (304.71) (380–1184) |
| Vascular dementia | 1 | 1 | M | 70 | 0.65 | 391 |
| Isolated CNS angiitis | 1 | 2 | F | 48 | 0.21 | 437 |
| Paraneoplastic disorders | ||||||
| Lambert-Eaton syndrome | 1 | 2 | M | 63 | 0.51 | 260 |
| Limbic encephalitis | 3 | 2 | 3F | 63.3 (14.64) | 0.55 (0.32) | 448 (122.87) (312–481) |
| Prion diseases | ||||||
| Creutzfeldt-Jacob disease | 5 | 2 | 5M | 65.2 (10.69) | 0.49 (0.12) | 536.6 (55.28) (491–618) |
| Other neurological disorders | ||||||
| Normal pressure hydrocephalus | 3 | 1 | 2M, 1F | 70.67 (2.88) | 0.43 (0.08) | 477.67 (575.77) (123–1142) |
| Myasthenia gravis | 1 | 2 | M | 40 | 0.45 | 588 |
| Pseudotumour cerebri | 4 | 2 | 4F | 36.25 (5.56) | 0.30 (0.09) | 533 (33.85) (498–563) |
| CNS neoplasm | 1 | 1 | M | 72 | 0.51 | 382 |
| Myoclonus-hyperexplexia | 1 | 2 | M | 50 | 0.23 | 531 |
| Lues | 1 | 2 | F | 32 | 0.22 | 501 |
| Miscellaneous neurological conditions | ||||||
| Fibromyalgia | 1 | 1 | M | 49 | 0.5 | 821 |
| Central vertigo | 3 | 1 | 2M, 1F | 39 (20.24) | 0.43 (0.13) | 695.33 (457.07) (177–1280) |
| Acute headache | 3 | 1 | 2M, 1F | 39.33 (15.82) | 0.47 (0.04) | 993.33 (55.51) (955–1057) |
| Epileptic seizures | 4 | 1,2 | 2M, 2F | 57.5 (9.54) | 0.39 (0.14) | 677.75 (213.88) (534–996) |
| Chronic sciatalgia | 1 | 1 | F | 34 | 0.55 | 583 |
| Cranio-cerebral trauma | 1 | 1 | F | 63 | 1.59 | 583 |
| Depression | 1 | 2 | M | 38 | 0.31 | 595 |
| Encephalitis | 1 | 2 | F | 23 | 0.21 | 589 |
| Other dementia | 1 | 2 | M | 71 | 0.42 | 456 |
| Recurrent attacks of dizziness | 1 | 2 | M | 62 | 0.40 | 1259 |