1st author | Quality* | Cs+† | Cs−‡ | Cnt+† | Cnt−‡ | Odds ratio | 95% CI |
---|---|---|---|---|---|---|---|
*P, studies with head injury X years prior to Alzheimer’s onset; Q, studies with matched informant type. | |||||||
†Cs+/Cnt+, number of cases/controls who had sustained a head injury with loss of consciousness. | |||||||
‡Cs−/Cnt−, number of cases/controls who had not sustained a head injury with loss of consciousness. | |||||||
Pre-Mortimer studies | |||||||
Mortimer (1985) | P | 20 | 54 | 11 | 108 | 3.64 | 1.52 to 8.99 |
Amaducci (1986) | P | 7 | 106 | 5 | 203 | 2.68 | 0.71 to 10.95 |
Chandra (1987) | Q | 6 | 51 | 1 | 56 | 6.00 | 0.73 to 276.02 |
Chandra (1989) | P, Q | 5 | 269 | 4 | 270 | 1.25 | 0.27 to 6.30 |
Broe (1990) | P | 8 | 162 | 6 | 164 | 1.33 | 0.41 to 4.66 |
Ferini-Strambi (1990) | P | 5 | 58 | 10 | 116 | 1.00 | 0.26 to 3.39 |
Graves (1990) | P, Q | 19 | 111 | 8 | 122 | 2.61 | 1.04 to 7.15 |
van Duijn (1992) | P | 22 | 176 | 17 | 181 | 1.33 | 0.65 to 2.77 |
Post-Mortimer studies | |||||||
Li (1992) | Q | 1 | 69 | 2 | 138 | 1.00 | 0.09 to 11.03 |
Fratiglioni (1993) | P, Q | 4 | 84 | 25 | 232 | 0.44 | 0.11 to 1.34 |
CSHA (1994) | P | 13 | 149 | 27 | 393 | 1.27 | 0.58 to 2.63 |
Forster (1995) | 22 | 87 | 16 | 93 | 1.50 | 0.68 to 3.41 | |
Rasmusson (1995) | P, Q | 4 | 64 | 1 | 33 | 2.06 | 0.19 to 104.59 |
O’Meara (1997) | 32 | 317 | 16 | 326 | 2.06 | 1.07 to 4.09 | |
Tsolaki (1997) | 14 | 47 | 15 | 54 | 1.07 | 0.43 to 2.66 |