Clinical characteristics of the two treatment groups
| Variable | Group 1: ICP/CPP guided (n=40) | Group 2: Ptio2 guided (n=53) | p Value |
|---|---|---|---|
| The values are median (25th, 75th centiles), absolute numbers (relative frequency), or mean (SD). | |||
| *Mann-Whitney U test. | |||
| †2 × 2 table χ2 test. | |||
| ‡Categories used: 1, bilateral and equal response; 2, bilateral and unequal response; 3, unilateral response; 4, bilateral no response. | |||
| §Computed tomography classification according to Marshall et al.19 | |||
| ICP, intracranial pressure; CPP, cerebral perfusion pressure; Ptio2, partial pressure of brain tissue oxygen. | |||
| Age | 30.8 (20.5, 46.9) | 31.1 (23.3, 56.2) | 0.29* |
| GCS | 6 (4, 7) | 6 (4, 7) | 0.51* |
| Pupillary response‡ | 1 (1, 3) | 1 (1, 3) | 0.19* |
| Initial hypotension (RRsys <90 mm Hg) | 11 (28%) | 18 (34%) | 0.66† |
| Initial hypoxia (SaO2 <90%) | 15 (38%) | 22 (42%) | 0.86† |
| Injury type§ | |||
| Diffuse I | 2 (5%) | 2 (4%) | |
| Diffuse II | 12 (30%) | 13 (25%) | |
| Diffuse III | 4 (10%) | 9 (17%) | |
| Diffuse IV | 2 (5%) | 3 (6%) | |
| Evacuated | 19 (48%) | 23 (43%) | |
| Non-evacuated | 1 (3%) | 3 (6%) | |
| Therapy intensity level | 11.2 (5.0) | 9.7 (5.6) | 0.18* |