General assessment of late outcome according to APOE genotype
| APOE genotype | ||
|---|---|---|
| ε4 negative | ε4 positive | |
| General assessment of functional outcome 15 to 25 years after a head injury for carriers and non-carriers of APOE ε4. | ||
| Values are n (%). | ||
| *These results are based on 418 patients: the 396 who underwent neuropsychological assessment together with a further 22 where GOSE and APOE genotype were available. | ||
| GOSE, extended Glasgow outcome scale; MMSE, mini-mental state examination. | ||
| MMSE, raw scores | ||
| 0–23 | 64 (22.9) | 27 (23.1) |
| 24–27 | 74 (26.5) | 30 (25.6) |
| 28–29 | 75 (26.9) | 29 (24.8) |
| 30 | 66 (23.7) | 31 (26.5) |
| MMSE , centile scores | ||
| ≤1% | 77 (27.6) | 35 (29.9) |
| 2–30% | 52 (18.6) | 23 (19.7) |
| 31–69% | 79 (28.3) | 28 (23.9) |
| 70–100% | 71 (25.4) | 31 (26.5) |
| Composite performance, centile scores | ||
| Test incomplete | 100 (35.5) | 35 (29.9) |
| 1–17% | 51 (18.3) | 35 (29.9) |
| 18–30% | 66 (23.7) | 21 (17.9) |
| 31–100% | 62 (22.2) | 26 (22.2) |
| GOSE at follow up* | ||
| Vegetative/lower severe disability | 52 (17.8) | 24 (19.0) |
| Upper severe disability | 40 (13.7) | 17 (13.5) |
| Lower moderate disability | 83 (28.4) | 38 (30.2) |
| Upper moderate disability | 28 (9.6) | 19 (15.1) |
| Lower good recovery | 41 (14.0) | 15 (11.9) |
| Upper good recovery | 48 (16.4) | 13 (10.3) |