Comparison of characteristics of patients with familial intracranial aneurysms (defined as the presence of at least two first degree relatives with aneurysmal subarachnoid haemorrhage) and an autosomal dominant or non-dominant pattern of inheritance (families from the present study and from published reports)
| This study | Published reports | |||||
|---|---|---|---|---|---|---|
| AD (n) | Non-AD (n) | Difference (95% CI) | AD (n) | Non-AD (n) | Difference (95% CI) | |
| ACA, anterior communication artery complex; AD, autosomal dominant inheritance; non-AD, mode of inheritance other than autosomal dominant; CI, confidence interval; ICA, internal carotid artery complex (including posterior communicating artery); MCA, middle cerebral artery complex; SAH, subarachnoid haemorrhage; VBA, vertebrobasilar artery complex. | ||||||
| Mean age at time of SAH (including proband) (years) | 45.0 (42), range 21 to 71 | 43.7 (42), range 22 to 63 | 1.3 (−4.5 to 6.7) | 44.9 (49) | 49.5 (29) | 4.6 (−2.2 to 11.0) |
| Mean age at time of SAH (excluding proband) (years) | 46.7 (29), range 24 to 71 | 42.5 (31), range 22 to 64 | 4.2 (−1.8 to 10.0) | |||
| Proportion of women | 63% (29) | 55% (27) | 8 (−12 to 28) | 65% (33) | 62% (21) | 3 (−18 to 24) |
| Multiple intracranial aneurysms | 18% (6) | 26% (9) | −8 (−27 to 11) | 11% (6) | 14% (5) | −3 (−17 to 11) |
| Outcome | ||||||
| Dead | 43% (18) | 43% (17) | 0 (−21 to 22) | |||
| Dependent | 5% (2) | 10% (4) | −5 (−17 to 6) | |||
| Independent | 52% (22) | 48% (19) | 4 (−17 to 27) | |||
| Site of intracranial aneurysms | ||||||
| ACA | 48% (19) | 35% (17) | 13 (−8 to 33) | 25% (14) | 21% (8) | 4 (−13 to 21) |
| MCA | 25% (10) | 29% (14) | −4 (−22 to 15) | 21% (12) | 31% (12) | −10 (−28 to 8) |
| ICA | 23% (9) | 29% (14) | −6 (−24 to 12) | 48% (27) | 49% (18) | −1 (−21 to 19) |
| VBA | 5% (2) | 8% (4) | −3 (−13 to 7) | 7% (4) | 3% (1) | 4 (−4 to 13) |