Primary efficacy variable
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Home diary data | | | | | |
Proportion ON time (%) | 57.6 (14.5) | 64.8 (14.0) | 59.3 (15.8) | 60.6 (16.7) | p<0.05 |
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Secondary efficacy variables
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Home diary data | | | | | |
ON time (h) | 9.5 (2.5) | 10.8 (2.4) | 10.1 (2.8) | 10.2 (2.9) | p<0.01 |
OFF time (h) | 7.0 (2.6) | 5.9 (2.5) | 6.9 (2.9) | 6.6 (2.8) | p<0.05 |
Levodopa dose (mg/d) | 700 (429) | 667 (322) | 705 (368) | 731 (377) | p<0.001 |
UPDRS | | | | | |
Mentation, behaviour, mood (part I) | 1.7 (1.9) | 2.0 (2.2) | 1.4 (1.6) | 1.5 (1.7) | p<0.01 |
ADL (part II) | 12.5 (5.7) | 12.0 (5.6) | 13.7 (6.9) | 12.6 (7.4) | NS |
Motor score (part III) | 24.3 (12.2) | 19.8 (11.6) | 23.6 (12.6) | 19.3 (12.6) | NS |
Total score (I, II, and III) | 38.4 (17.3) | 33.7 (17.0) | 38.7 (17.9) | 33.2 (20.0) | NS |
Scheduled levodopa dose (mg/d) | 684 (393) | 667 (334) | 683 (356) | 705 (369) | p<0.001 |