Table 1

APOE, IL-1A, and IL-1B genotype frequencies (together with control data) and mean (SD) microglial cell loads for 68 patients with Alzheimer’s disease (AD)

Gene/Genotype	Genotype frequency		Microglial cell load (% area covered)
Gene/Genotype	AD	Control*†	Microglial cell load (% area covered)
Previously published¹⁶ IL-1 control data from non-demented patients of the Birmingham/Manchester/Scottish UK control cohort is presented for comparison. †Previously unpublished APOE control data from the same Birmingham/Manchester/Scottish UK control cohort; p<0.05 compared with the CC genotype.
APOE	n = 68	n = 479
E2/E3	0.06	0.10	0.58 (0.26)
E2/E4	0.02	0.02	0.38
E3/E3	0.34	0.61	0.75 (0.53)
E3/E4	0.43	0.25	0.68 (0.57)
E4/E4	0.16	0.02	0.63 (0.39)
IL-1A −889 C/T	n = 68	n = 503
CC	0.44	0.44	0.59 (0.57)
CT	0.46	0.43	0.73 (0.43)
TT	0.10	0.12	0.94 (0.47)‡
T allele bearers	0.56	0.56	0.77 (0.52)‡
IL-1B −511 C/T	n = 68	n = 479
CC	0.50	0.44	0.61 (0.39)
CT	0.35	0.46	0.77 (0.63)
TT	0.15	0.10	0.85 (0.67)
T allele bearers	0.50	0.56	0.81 (0.63)