Genotype and allele frequencies of LBP-1c/CP2/LSF gene 3′ UTR polymorphism in patients with Alzheimer’s disease and non-demented age and sex matched controls
| Age at onset and at collection (SD) (years) | Genotype, n (frequency (95% CI)) | Allele, n (frequency (95% CI)) | ||||
|---|---|---|---|---|---|---|
| GG | GA | AA | G | A | ||
| CI, confidence interval; EAOD, early onset Alzheimer’s disease; LOAD, late onset Alzheimer’s disease; n, number of individuals genotyped. | ||||||
| All cases of Alzheimer’s disease (n = 166) | 67.6 (10.8) | 147 | 19 | 0 | 313 | 19 |
| (0.89 (0.93 to 0.84)) | (0.11 (0.16 to 0.07)) | (0.0 (0.0–)) | (0.94 (0.97 to 0.92)) | (0.06 (0.08 to 0.03)) | ||
| All controls (n = 225) | 71.3 (11.4) | 216 | 9 | 0 | 441 | 9 |
| (0.96 (0.99 to 0.93)) | (0.04 (0.07 to 0.01)) | (0.0 (0.0–)) | (0.98 (0.99 to 0.97)) | (0.02 (0.03 to 0.01)) | ||
| LOAD (⩾70 years) (n = 95) | 76.1 (4.4) | 86 | 9 | 0 | 181 | 9 |
| (0.91 (0.95 to 0.83)) | (0.9 (0.17 to 0.05)) | (0.0 (0.39 to 0.0)) | (0.95 (0.98 to 0.91)) | (0.05 (0.09 to 0.03)) | ||
| Controls ⩾70 years (n = 193) | 77.8 (5.2) | 184 | 9 | 0 | 377 | 9 |
| (0.95 (0.98 to 0.91)) | (0.05 (0.09 to 0.03)) | (0.0 (0.02 to 0.0)) | (0.98 (0.99 to 0.96)) | (0.02 (0.04 to 0.01)) | ||
| EOAD (<70 years) (n = 71) | 61.5 (4.5) | 61 | 10 | 0 | 132 | 10 |
| (0.86 (0.92 to 0.76)) | (0.14 (0.24 to 0.08)) | (0.0 (0.05 to 0.0)) | (0.93 (0.96 to 0.88)) | (0.07 (0.13 to 0.04)) | ||
| Controls <70 years (n = 32) | 64.1 (4.3) | 32 | 0 | 0 | 64 | 0 |
| (1.0 (1.00 to 0.89)) | (0.0 (0.11 to 0.0)) | (0.0 (0.11 to 0.0)) | (1.0 (1.00 to 0.94)) | (0.0 (0.06 to 0.0)) | ||