Sensitivity to change four weeks following the first botulinum toxin treatment in de novo patients (n = 51) with craniocervical dystonia
| CDQ-24 subscale | Baseline score Mean (SD) | Score at four weeks Mean (SD) | Effect size | p value* |
|---|---|---|---|---|
| *Baseline v 4 weeks: Wilcoxon’s matched-pairs test. | ||||
| SD, standard deviation. | ||||
| Stigma | 44.7 (24.2) | 27.3 (19.6) | 0.72 | <0.001 |
| Emotional wellbeing | 38.3 (25.7) | 27.2 (22.5) | 0.43 | <0.001 |
| Pain | 39.1 (26.8) | 26.3 (23.4) | 0.47 | <0.001 |
| Activities of daily living | 45.5 (24.7) | 32.5 (23.3) | 0.53 | <0.001 |
| Social/family life | 21.0 (23.8) | 11.4 (15.3) | 0.40 | 0.002 |
| Total score all patients | 38.9 (19.9) | 25.8 (16.7) | 0.67 | <0.001 |
| Cranial dystonia (n = 20) | 41.2 (17.4) | 28.3 (17.6) | 0.73 | 0.01 |
| Cervical dystonia (n = 31) | 37.4 (21.5) | 24.1 (16.2) | 0.62 | <0.001 |