Table 3

Peak voxel localisation and significance of the brain regions characterised by significant metabolic differences between AD genotypic subgroups (e4 non-carriers, e3/e4, and e4/e4). Results reaching significance at p<0.001 and at p<0.005 are presented in separate sections.

Region	Brodmann area	Coordinates (mm)†			Z value	p values
Region	Brodmann area	x	y	z	Z value	p values
†Coordinates from the atlas of Talairach and Tournoux:²⁷x is the distance in mm to the right (+) or left (−) of midline, y is the distance anterior (+) or posterior (−) to the anterior commissure, and z is the distance superior (+) or inferior (−) to a horizontal plane through the anterior and posterior commissures.
*Uncorrected for multiple comparisons.
Pre-central gyrus	6	−20	−19	63	3.80	<0.001*
	6	18	−17	65	3.68
	4	−18	−24	60	3.82
	4	18	−29	58	3.52
Middle occipital gyrus	18	28	−93	10	3.80
Anterior cingulate cortex	32	−10	23	25	3.68
Medial frontal gyrus	8	−3	34	43	2.76	<0.005**
Medial frontal gyrus	8	5	49	40	2.57
Superior temporal gyrus	38	−44	13	−11	2.32
Superior temporal gyrus	38	53	7	−12	2.64
Middle occipital gyrus	18	−7	−82	21	2.80
Posterior cingulate cortex	23	−4	−30	24	2.81
Anterior cingulate cortex	24	4	13	27	2.56
Parahippocampal gyrus	36	−27	−20	−24	2.71