Symptom variability by self assessed motor fluctuations
| “Off” | “Partial off” | “On” | “On with dyskinesias” | p Value†† | |
|---|---|---|---|---|---|
| Data are median (interquartile range) except where indicated. | |||||
| *Section III (motor examination) of the UPDRS (possible score range, 0–108).1 | |||||
| †Item 20 of section III (motor examination) of the UPDRS (possible score range, 0–20).1 | |||||
| ‡Item 22 of section III (motor examination) of the UPDRS (possible score range, 0–20).1 | |||||
| §Item 30 of section III (motor examination) of the UPDRS (possible score range, 0–4).1 | |||||
| ¶Mean (SD) number of hand/arm movements between two points 30 cm apart during 20 seconds (mean of left and right arm).5 | |||||
| **Mean (SD) time (s) to walk 2×7 metres.5 | |||||
| ††Kruskal-Wallis analysis of variance (corrected for multiple comparisons). | |||||
| ‡‡p<0.05 v “off” (post hoc Mann–Whitney U tests corrected for multiple comparisons). | |||||
| §§p<0.05 v “partial off” (post hoc Mann–Whitney U tests corrected for multiple comparisons). | |||||
| ¶¶p<0.05 v “on” (post hoc Mann–Whitney U tests corrected for multiple comparisons). | |||||
| PD, Parkinson’s disease; CDRS, clinical dyskinesia rating scale.3 | |||||
| Overall PD motor symptoms* | 38 (25.5 to 49.2) | 23.5 (16 to 33.4)‡‡ | 15 (9.5 to 23)‡‡§§ | 14 (9 to 17)‡‡§§ | <0.001 |
| Resting tremor† | 1 (0 to 3.5) | 0 (0 to 3.8) | 0 (0 to 0)‡‡§§ | 0 (0 to 0)‡‡§§ | <0.001 |
| Rigidity‡ | 4 (3.0 to 8.5) | 1.5 (0 to 4)‡‡ | 0.5 (0 to 2)‡‡ | 1 (0 to 1)‡‡§§ | <0.001 |
| Postural stability§ | 1 (1 to 2) | 1 (1 to 2) | 1 (1 to 2) | 1 (1 to 1) | 0.136 |
| Upper limb bradykinesia¶ | 20.2 (3.7) | 26.4 (5.6)‡‡ | 27.3 (5.8)‡‡ | 31.2 (6.9)‡‡§§ | <0.001 |
| Walking time** | 36.7 (30.2) | 14.7 (10.5)‡‡ | 13.7 (4.8)‡‡ | 12.9 (3.7)‡‡ | <0.001 |
| CDRS hyperkinesias | 0 (0 to 1) | 1 (0 to 4) | 2 (0 to 4) | 8.5 (6 to 12)‡‡§§¶¶ | <0.001 |
| CDRS dystonia | 0 (0 to 3) | 0 (0 to 0.8) | 0 (0 to 0) | 0 (0–1) | 0.184 |