Association between Parkinson’s disease and the H1 haplotype in the Tau gene
| n | H1|H1% (n) | H1|H2% (n) | H2|H2% (n) | OR (95% CI) H1|H1 v H1|H2 + H2|H2 | p Value | |
|---|---|---|---|---|---|---|
| *Median age at onset. | ||||||
| †24 H1|H1 controls and 19 H1|H1 cases carried the exon 9 polymorphism on one of the H1 haplotypes; 13 H1|H2 controls and 1 H1|H2 case carried the exon 9 polymorphism on the H1 haplotype. No H2|H2 cases or controls carried the exon 9 polymorphism. | ||||||
| ‡Interaction between H1|H1 and age at onset, p = 0.05. | ||||||
| §Tau haplotypes were in Hardy-Weinberg equilibrium among controls (p = 0.66). | ||||||
| ¶Interaction between H1|H1and sex was not significant. | ||||||
| Overall† | ||||||
| Controls | 483 | 52.4 (253) | 41.0 (198) | 6.6 (32)§ | ||
| Cases | 208 | 64.4 (134) | 31.3 (65) | 4.3 (9) | 1.71 (1.20 to 2.43) | 0.003 |
| Men | ||||||
| Controls | 284 | 51.8 (147) | 42.9 (122) | 5.3 (15) | ||
| Cases | 118 | 65.3 (77) | 30.5 (36) | 4.2 (5) | 1.86 (1.15 to 2.99)¶ | 0.01 |
| Women | ||||||
| Controls | 199 | 53.3 (106) | 38.2 (76) | 8.5 (17) | ||
| Cases | 90 | 63.3 (57) | 32.2 (29) | 4.5 (4) | 1.54 (0.91 to 2.63)¶ | 0.11 |
| Onset ⩽65 years* | ||||||
| Controls | 264 | 53.4 (141) | 39.4 (104) | 7.2 (19) | ||
| Cases | 116 | 72.4 (84) | 27.6 (32) | – | 2.52 (1.49 to 4.25)‡ | <0.001 |
| Onset >65 years* | ||||||
| Controls | 219 | 51.2 (112) | 42.9 (94) | 5.9 (13) | ||
| Cases | 92 | 54.3 (50) | 35.9 (33) | 9.8 (9) | 1.20 (0.73 to 1.98)‡ | 0.47 |