Table 2

Summary of positron emission tomography (PET) findings in parkinsonian syndromes

PET tracerParkinson’s diseaseProgressive supranuclear palsyMultiple system atrophyCorticobasal degeneration
18F-DopaAsymmetric reduction (putamen > caudate)Symmetrical reduction (caudate  =  putamen)Symmetrical reduction (caudate  =  putamen)Asymmetric reduction (caudate  =  putamen)
18FDGNormal/raised in striatum. Reduced in temporoparietal cortexReduced in bilateral striatum and frontal corticesReduced in striatum, brainstem, and cerebellumAsymmetric reduction in striatum, thalamus, frontal and temporoparietal cortices