Table 1

 Multivariate Cox regression model of survival in amyotrophic lateral sclerosis: Scottish Motor Neurone Disease Register 1989–98

BSEpHazard ratio (95% CI)
Time  = 0 yearsTime  = 1 yearTime  = 2 years
*These covariates have a time dependent component.
SE, standard error.
All cases
    Year of diagnosis0.0750.0120.0001.08 (1.05 to 1.10)
    Increasing age at onset0.0220.0030.0001.02 (1.01 to 1.03)
    Bulbar onset0.2320.0740.0021.25 (1.09 to 1.46)
    Mixed upper and lower syndrome0.2020.0970.0361.23 (1.01 to 1.49)
    Specialist neurology assessment*−0.5810.1670.0010.56 (0.40 to 0.77)0.66 (0.40 to 0.78)0.78 (0.66 to 0.92)
    Use of riluzole*−1.4520.2640.0000.24 (0.14 to 0.42)0.31 (0.14 to 0.39)0.41 (0.29 to 0.58)
    Time from onset to diagnosis*−0.9760.0630.0000.38 (0.33 to 0.42)0.40 (0.36 to 0.45)0.43 (0.39 to 0.48)
    Sex*0.1890.1100.0851.21 (0.97 to 1.50)1.11 (0.97 to 1.50)1.02 (0.89 to 1.16)
Lower motor neurone syndromes excluded
    Year of diagnosis0.0470.0130.0001.05 (1.02 to 1.08)