Table 1

Patient characteristics at baseline

Clozapine (N = 32)Placebo (N = 28)
Values are mean (SD).
*Higher scores indicate more severe impairment; †lower scores indicate more severe impairment.
CGI, clinical global impression scale; MMSE, mini mental test examination; PANSS, positive and negative syndrome scale; PD, Parkinson’s disease; UPDRS, unified Parkinson’s disease rating scale.
Age (years)71.2 (7.4)72.8 (8.2)
    Sex
    Male56%50%
Female44%50%
Duration of PD (years)12.1 (5.7)11.3 (5.4)
Hoehn and Yahr stage3.3 (0.9)3.1 (1.4)
UPDRS scores*
    Total52.6 (21.1)52.7 (19.8)
    Motor31.5 (14.2)31.4 (13.2)
    Schwab and England67.4 (20.8)70.7 (18.6)
Levodopa dosage (mg/day)788 (390)733 (489)
Positive PANSS*17.8 (4.7)15.3 (5.0)
CGI*5.1 (0.8)4.9 (0.9)
MMSE†26.1 (3.0)24.1 (2.8)