Table 3

Haplotype analysis in seven unrelated SCA2 pedigrees with microsatellites which flank the SCA2 locus

SCA2 pedigrees	Allele marker
SCA2 pedigrees	D12S1328	D12S1332	D12S1672	CAG repeat	D12S1333
Seven pedigrees in which DNA from more than one individual was available (pedigrees I–VII) are shown. The remaining nine families with DNA from only one affected were not analysed. Alleles were assigned with reference to CEPH individual 134702. Where alleles were not previously described, the next available number was assigned. Where phase was not determinable, the genotype segregating with the disease is given.
*Indicates possible common disease associated haplotypes.
SCA2, spinocerebellar ataxia type 2.
I	3	3	4		2/3*
II	4/2	3	2/9		2*
III	3/7*	3/11*	8*		2*
IV	3*	3*	8*		2/5*
V	3/4*	3*	8*		2/5*
VI	3/7*	3*	8/9*		2/5*
VII	4/8	3/7	2/9		2/5*