Comparison of change scores in patients taking clozapine compared with the placebo group at the end of period II (PII)
| Scores | Clozapine (N = 32) | Placebo (N = 28) | |||||
|---|---|---|---|---|---|---|---|
| Baseline | End of PII | Δ End PII* | Baseline | End of PII | Δ End PII* | Between group comparison† | |
| Values are mean (SD). | |||||||
| *95% confidence interval and p value for within group t test on change from baseline also shown; †t statistic, degrees of freedom (df), and p value for between group t test on change from baseline also shown. | |||||||
| CGI, clinical global impression scale; PANSS, positive and negative syndrome scale. | |||||||
| CGI | 5.1 (0.8) | 3.3 (1.5) | −1.8 (1.5); −2.3 to −1.3; p<0.0001 | 4.9 (0.9) | 4.3 (1.5) | −0.6 (1.1); −1 to −0.2; p = 0.011 | t = −3.45; df = 58; p = 0.001 |
| Positive PANSS | 17.8 (4.7) | 12.3 (4.1) | −5.6 (3.9); −6.9 to −4.3; p<0.0001 | 15.3 (5.0) | 14.5 (5.7) | −0.8 (2.8); −1.8 to 0.2; p = 0.127 | t = −5.37; df = 58; p<0.0001 |