Comparison of change scores in patients taking clozapine compared with the placebo group at the end of period III (PIII)
| Scores | All patients (N = 54) | Formerly clozapine† (N = 30) | Formerly placebo† (N = 24) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | End PIII | Δ End PIII* | Baseline | End PIII | Δ End PIII* | Baseline | End PIII | Δ End PIII* | |
| Values are mean (SD). | |||||||||
| *95% confidence interval and p value for within group t test on change from baseline also shown; †according to treatment group in period II. | |||||||||
| CGI, clinical global impression scale; PANSS, positive and negative syndrome scale. | |||||||||
| CGI | 5.0 (0.9) | 2.8 (1.3) | −2.2 (1.55); −2.6 to −1.8; p<0.0001 | 5.1 (0.8) | 2.6 (1.5) | −2.5 (1.6); −3.1 to −1.9; p<0.0001 | 4.9 (1.0) | 3.1 (1.1) | −1.8 (1.4); −2.4 to −1.2; p<0.0001 |
| Positive PANSS | 16.9 (5.1) | 10.5 (3.6) | −6.4 (5.5); −7.9 to −4.9; p<0.0001 | 17.8 (4.8) | 10.1 (3.7) | −7.7 (5.5); −9.7 to −5.7; p<0.0001 | 15.7 (5.4) | 10.9 (3.6) | −4.8 (5.3); −6.9 to −2.7; p = 0.0002 |