Total brain MRI segmentation and lobar cortical GM.
| Healthy controls | Very mild AD | Mild AD | Moderate to severe AD | |
|---|---|---|---|---|
| All values are expressed as % mean (SD) of TIV. | ||||
| One way analysis of variance: *p<0.05 compared with controls: †p<0.001 compared with controls; ‡p<0.01 compared with very mild AD; §p<0.001 compared with very mild AD. | ||||
| One way multiple analysis of covariance: for all four lobes, cortical GM, p = 0.002. | ||||
| Post hoc Tukey test: **p<0.05 compared with controls; ††p<0.001 compared with controls; ‡‡p<0.05 compared with very mild AD; §§p<0.01 compared with very mild AD. | ||||
| CGM, cortical grey matter. | ||||
| Total brain MRI segmentation | ||||
| CGM | 41.6 (2.2) | 41.2 (2.1) | 39.3 (30)* | 37.2 (2.5)†§ |
| WM | 32.9 (3.9) | 30.2 (2.9)* | 27.3 (3.4)†‡ | 26.3 (2.7)†‡ |
| Total CSF | 13.2 (5.5) | 16.5 (4.1) | 21.5 (4.7)†§ | 24.6 (3.6) ‡§ |
| WMH | 2.7 (2.4) | 4.6 (5.9) | 8.0 (8.5) | 10.1 (11.2) |
| Lobar cortical GM | ||||
| Frontal | 16.4 (1.2) | 16.1 (1.1) | 15.2 (1.6)** | 14.3 (1.3)††§§ |
| Temporal | 10.5 (0.7) | 10.2 (0.9) | 9.7 (0.8)** | 9.1 (0.7)††§§ |
| Parietal | 9.5 (0.6) | 9.5 (0.7) | 9.1 (1.0) | 8.6 (0.7)**‡‡ |
| Occipital | 5.1 (0.4) | 5.2 (0.7) | 5.2 (0.6) | 5.0 (0.5) |