Table 2

Diagnostic criteria for variant CJD

*Depression, anxiety, apathy, withdrawal, delusions.
†This includes both frank pain, unpleasant dysaesthesia, or both.
‡Generalised triphasic complexes at about 1 Hz.
§Spongiform change and extensive prion protein deposition with florid plaques throughout cerebrum and cerebellum.
EEG, electroencephalogram; vCJD, variant Creutzfeldt-Jakob disease.
I A: Progressive neuropsychiatric disorder
B: Duration of illness more than six months
C: Routine investigations do not suggest an alternative diagnosis
D: No history of potential iatrogenic exposure
II A: Early psychiatric symptoms*
B: Persistent painful sensory symptoms†
C: Ataxia
D: Myoclonus, chorea, or dystonia
E: Dementia
III A: EEG does not show typical appearance of sporadic CJD‡ (or no EEG done)
B: Bilateral pulvinar high signal on magnetic resonance imaging
Definite vCJD IA (progressive neuropsychiatric disorder) and neuropathological confirmation of vCJD§
Probable vCJD I and 4/5 of II and IIIA and IIIB
Possible vCJD I and 4/5 of II and IIIA