Table 3

 Adjusted effects of niacin intake from food (per ln increase in intake (mg)) on the rate of cognitive change over 6 years, among the total cohort of 3718 participants, and among 2824 participants with no history of stroke or myocardial infarction at baseline or first follow up, Chicago Health and Aging Project, 1993–2002

Total cohort (n = 3718)Excluding participants with stroke or myocardial infarction (n = 2824)*Excluding participants with low cognitive scores (n = 3158)†
ModelβSEpβSEpβSEp
*Multiple adjusted model does not include terms for stroke or heart disease.
†Lowest 15% of scores distribution.
‡Includes age (years), age2, sex, race, education (years), education2 interactions between sex and age, sex and education, and race and education, time, niacin intake from foods (continuous log transformed), and interactions between time and age, education, education squared, and niacin intake.
§Includes terms from the basic-adjusted model plus vitamin E intake from food sources (ln(IU/day)), total intakes of vitamins C (ln(mg/day)), beta-carotene (ln(IU/day), folate (ln(μg/day)), diabetes, hypertension, ever smoked (yes/no), pack years of smoking, alcohol use (g/day), multivitamin use, history of stroke, heart disease, and interactions between time and each of these covariates.
Basic adjusted‡0.0190.0090.050.0280.0100.0040.0230.0100.02
Multiple adjusted§0.0170.0110.120.0350.0100.0020.0250.0110.03