Table 2

 Mechanisms of serotonin overstimulation

MechanismDrugs
MAOIs, monoamine oxidase inhibitors; SSRIs, selective serotonin reuptake inhibitors; TCAs, tricyclic antidepressants.
Drugs metabolised to serotonin or promoting serotonin releaseLevodopa, lithium, MAOIs, tryptophan, trazodone, tetrabenazine
Inhibition of serotonin reuptakeSSRIs, TCAs, trazodone, tramadol, St John’s wort, venlafaxine
Inhibition of serotonin metabolismMAOIs (phenelzine, isocarboxid, selegiline), St John’s wort
Postsynaptic receptor stimulationBuspirone, triptans, lithium, carbamazepine