Percentage frequency of Neuropsychiatric Inventory disturbances in patients with different types dementia classified by dementia severity
| NPI domain | CDR = 1 | CDR = 2 | CDR = 3 | Total | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AD (n = 188) | sVaD (n = 82) | cVaD (n = 11) | AD (n = 107) | sVaD (n = 59) | cVaD (n = 14) | AD (n = 25) | sVaD (n = 20) | cVaD (n = 10) | AD (n = 320) | sVaD (n = 161) | cVaD (n = 35) | |||||||||||||
| NPI, Neuropsychiatric Inventory, CDR, clinical dementia rating, AD, Alzheimer’s disease, sVaD, subcortical vascular dementia, cVaD, cortical vascular dementia. *Significant difference in prevalence of different CDR group among patients with Alzheimer disease (p<0.01, χ2 test); †significant difference in prevalence of different CDR group among patients with subcortical vascular dementia (p<0.01, χ2 test); ‡significant difference in prevalence of different CDR group among patients with cortical vascular dementia (p<0.01, χ2 test). | ||||||||||||||||||||||||
| Delusions*† | 19.9 | 14.1 | 9.1 | 43.9 | 45.9 | 35.7 | 58.3 | 60.9 | 50.0 | 31.0 | 31.1 | 31.4 | ||||||||||||
| Hallucinations*† | 13.9 | 21.6 | 18.2 | 34.6 | 24.6 | 14.3 | 58.3 | 60.9 | 50.0 | 24.1 | 21.0 | 25.7 | ||||||||||||
| Depression | 46.3 | 39.1 | 45.5 | 44.3 | 49.2 | 42.9 | 54.2 | 47.8 | 70.0 | 46.7 | 45.0 | 51.0 | ||||||||||||
| Anxiety | 32.6 | 28.3 | 63.5 | 43.0 | 38.3 | 42.9 | 44.0 | 52.2 | 60.0 | 37.2 | 33.8 | 51.0 | ||||||||||||
| Apathy*‡ | 43.6 | 42.4 | 36.4 | 55.1 | 49.2 | 57.1 | 64.0 | 60.9 | 100 | 41.6 | 47.2 | 62.9 | ||||||||||||
| Irritability | 38.0 | 42.4 | 36.4 | 45.8 | 36.1 | 50.0 | 50.0 | 60.9 | 70.0 | 42.0 | 41.6 | 51.4 | ||||||||||||
| Euphoria | 5.3 | 12.0 | 9.1 | 9.3 | 13.1 | 7.1 | 16.0 | 30.4 | 20.0 | 7.5 | 14.9 | 11.0 | ||||||||||||
| Agitation/aggression* | 28.9 | 39.1 | 45.5 | 49.5 | 47.5 | 71.4 | 64.0 | 52.2 | 70.0 | 38.8 | 44.1 | 62.9 | ||||||||||||
| Disinhibition* | 13.4 | 18.5 | 9.1 | 32.1 | 26.2 | 35.7 | 32.0 | 45.5 | 60.0 | 21.1 | 24.0 | 34.3 | ||||||||||||
| Aberrant motor activity*† | 17.2 | 18.5 | 18.2 | 49.1 | 35.0 | 23.1 | 60.0 | 65.2 | 40.0 | 31.4 | 30.0 | 26.5 | ||||||||||||
| Sleep disturbance† | 36.9 | 38.5 | 63.6 | 47.7 | 57.4 | 64.3 | 56.0 | 69.6 | 70.0 | 42.2 | 49.4 | 65.7 | ||||||||||||
| Appetite change | 30.5 | 34.1 | 45.5 | 40.6 | 39.3 | 35.7 | 52.2 | 63.6 | 60.0 | 35.6 | 40.3 | 45.7 | ||||||||||||