Table 1

Elgibility criteria, mild cognitice impairment inclusion criteria, and exclusion criteria for depression and vascular comorbidity

Study	Eligibility criteria*			MCI inclusion criteria		Exclusion criteria
Study	Age (years)	MMSE score	Other	Functional impairment	Test impairment	Depression	Vascular
*All studies required that the subject was not demented at baseline.
†Scale or test was not used in the Maastricht Memory Clinic. An equivalent scale or test was used if possible as described in the text.
BDRS, Blessed dementia rating scale; CDR, clinical demetia rating scale; Edu, years of education; GDS, geriatric depression scale; HDRS, Hamilton depression rating scale; LM-A, delayed recall score of story A from the logical memory test of the Wechsler memory scale; LM, logical memory test from the Wechsler memory scale–revised; m-HIS, modified Hachinski ischaemic scale; MMSE, mini-mental state examination; NYU, New York University paragraph recall.
Gal-Int-11	>50	–	–	CDR 0.5†	NYU <11†	Moderately severe depression	–

InDDEx	55 to 85	–	–	CDR 0.5†	NYU <9†	HDRS >12; HDRS item 1>1; DSM-IV major depression	m-HIS>4

ADCS-MIS	55 to 90	>23	–	CDR 0.5†	Edu <8: LM-A <3†	HDRS >12	m-HIS>4
					Edu 8–15: LM-A <5†
					Edu >15: LM-A <9†

Ampakine	55 to 80	>24	–	CDR 0.5†	Edu <8: LM-A <5†	GDS >6†	m-HIS>4
					Edu 8–15: LM-A <8†
					Edu >15: LM-A <13†

Piracetam	50 to 90	–	Score of at least one point above the lowest possible score on 7 of 8 tests from a cognitive battery†	CDR 0.5†	LM immediate recall <10 or difference immediate and delayed recall LM >5†	HDRS >17†	–

Rofecoxib	>65	>23	BDRS: score <4 on sum items 1–12 and score on first 8 items all <1	CDR 0.5†	RAVLT summed immediate recall < 38	HDRS >12	m-HIS>4