Table 4

HAART related drug toxicities

DrugToxicity
Nucleoside reverse transcriptase inhibitors (NRTIs)
Class associatedLactic acidosis, hepatic steatosis, lipodystrophy
Drug specific
    ZidovudineMyelosuppression, myopathy
    Stavudine (d4T)Peripheral neuropathy
    Zalcitabine (ddC)Peripheral neuropathy
    Didanosine (ddI)Peripheral neuropathy, pancreatitis
    Lamivudine (3TC)? Neuropathy
Non-NRTIs
    EfavirenzDysphoria, mood changes, vivid dreams, hypercholesterolaemia
    NevirapineHepatitis, Stevens-Johnson syndrome
Protease inhibitors
Class associatedLipodystrophy, hyperlipidaemia, diabetes
Drug specific
    NefinavirDiarrhoea
    IndinivirNephrolithiasis
    RitonivirPerioral dysaesthesia, flushing, diarrhoea, hyperuricaemia
    AmprenivirDiarrhoea
    LopinivirDiarrhoea