Table 1

 Results of cerebrospinal fluid and serum sample analysis after admission (as far as we know this is the first time that markers of cell damage and immune reaction have been measured in a patient with acute toscana virus meningoencephalitis)

Reference rangeDay 2Day 6Day 13Day 27
CSF, cerebrospinal fluid; EIA, enzyme immunosorbent assay; IFA, immunofluorescence assay; NA, not assessed; WBC, white blood cell.
WBC count (cells/mm3)0 to 5265603016
Lactate (mmol/l)1.1 to
Glucose (mmol/l)2.78 to 4.167.336.164.884.50
Total protein (mg/dl)15–4547322528
Oligoclonal bandingNegativeNegativeOne bandNegativeNegative
Tau protein (pg/ml)<350194NA191332
β2-Microglobulin (mg/l)<2NA53.23.1
Neurone specific enolase (ng/ml)<
S-100 protein (pg/ml)<2300NA1030NA644
Anti-TOSV antibodies in CSF
    IgG IFA<1:101:201:801:25601:5120
    IgM IFA<1:10<1:10<1:10<1:10<1:10
    IgG EIA +
    IgM EIA + + + +
Anti-TOSV antibodies in serum
    IgG IFA<1:101:6401:25601:51201:10240
    IgM IFA<1:101:801:3201:1601:160
    IgG EIA++++
    IgM EIA++++