Table 1

Classification of immune deficient conditions

Primary/inherited immune deficiency states
Antibody deficiency
Combined antibody and cellular immunodeficiency
Complement deficiency
Secondary/acquired immune suppression (non-HIV)
  • Extremes of age

  • Diabetes

  • Chronic alcoholism

  • Connective tissues disease

  • Organ failure (renal failure, hepatic failure)

  • Malignancy (especially haematological and lymphoreticular)

  • Iatrogenic

    • – chemotherapy

    • – radiotherapy

    • – transplantation

  • Asplenism/splenic dysfunction (primary or secondary—for example, sickle cell disease, trauma)