Clinical features of 71 patients with cryoglobulinaemic neuropathy (CN)
| Pattern | “Pure” CN (1) | “Comorbid” neuropathy (2) | Total | p (1 v 2)* |
|---|---|---|---|---|
| *Fisher’s exact test except †Mann–Whitney U test for differences between Rankin scores. | ||||
| LFSN, large fiber sensory neuropathy; MAPs, motor action potentials; NS, not significant; RLS, restless legs syndrome; SAPs, sensory action potentials; SFSN, small fiber sensory neuropathy. | ||||
| Number | 54 | 17 | 71 | |
| Sensory neuropathy (n (%)) | 41 (76) | 11 (65) | 52 (73) | NS |
| Asymmetrical | 13 (24) | 2 (12) | 15 (21) | NS |
| SFSN | 14 (26) | 4 (24) | 18 (25) | NS |
| LFSN | 27 (50) | 7 (41) | 34 (48) | NS |
| Sensorimotor neuropathy (n (%)) | 8 (15) | 5 (29) | 13 (18) | NS |
| Mononeuritis multiplex (n (%)) | 5 (9) | 1 (6) | 6 (8) | NS |
| Symptoms (n (%)) | ||||
| Tingling | 33 (61) | 6 (35) | 39 (55) | NS |
| Sensory ataxia | 21 (39) | 6 (35) | 27 (38) | NS |
| Thermal dysesthesia | 24 (44) | 6 (35) | 30 (42) | NS |
| Pain | 19 (35) | 11 (65) | 30 (42) | 0.048 |
| RLS | 27 (50) | 5 (29) | 32 (45) | NS |
| Rankin score (1/2/3/4) | 16/29/8/1 | 3/10/4/0 | 19/39/12/1 | NS† |
| Absent ankle jerks (n (%)) | 26 (48) | 9 (53) | 35 (49) | NS |
| Reduced/absent MAPs (n (%)) | 28 (52) | 7 (41) | 35 (49) | NS |
| Reduced/absent SAPs (n (%)) | 40 (74) | 13 (76) | 53 (75) | NS |