Comparison of 54 patients with “pure” cryoglobulinaemic neuropathy
| Cryoglobulinaemic syndrome | p* | ||
|---|---|---|---|
| Active (n = 21) | Mild (n = 33) | ||
| *Fisher’s exact test, except †t test, and ‡Mann–Whitney U test for differences between Rankin scores. | |||
| LFSN, large fiber sensory neuropathy; MAPs, motor action potentials; NS, not significant; RLS, restless legs syndrome; SAPs, sensory action potentials; SFSN, small fiber sensory neuropathy. | |||
| Age in years (mean (SD)) | 64.62 (7.20) | 62.91 (10.41) | NS† |
| Duration in years (mean (SD)) | 7.56 (5.87) | 4.79 (5.6) | NS† |
| Pattern | |||
| Sensory neuropathy (n (%)) | 10 (48) | 31 (94) | <0.001 |
| Asymmetrical | 3 (14) | 10 (30) | NS |
| SFSN | 0 (0) | 14 (42) | <0.001 |
| LFSN | 10 (48) | 17 (52) | NS |
| Sensorimotor neuropathy | 7 (33) | 1 (3) | 0.004 |
| Mononeuritis multiplex | 4 (19) | 1 (3) | 0.069 |
| Symptoms | |||
| Tingling | 15 (71) | 18 (55) | NS |
| Sensory ataxia | 12 (57) | 9 (27) | 0.045 |
| Thermal dysesthesia | 8 (38) | 16 (48) | NS |
| Pain | 8 (38) | 11 (33) | NS |
| RLS | 10 (48) | 17 (52) | NS |
| Rankin score (1/2/3/4) | 3/12/5/1 | 13/17/3/0 | 0.06‡ |
| Absent ankle jerks | 13 (62) | 13 (39) | NS |
| Reduced/absent MAPs | 15 (71) | 13 (39) | 0.028 |
| Reduced/absent SAPs | 21 (100) | 19 (57) | <0.001 |