Clinical and other parameters in the 45 patients with herpes simplex virus encephalitis included in the present study
| Patient no. | (1) Sex | (2) Age* | (3) Days† | (4) GCS score‡ | CSF examinations | (7) Corticosteroid administration** | Neuroradiological findings | (10) Detection of PLEDs on EEG¶¶ | Outcome§§ | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| (5) Initial leucocyte cell count¶ | (6) Initial CSF protein§ | (8) Detection of lesion by initial CT†† | (9) Detection of lesion by initial MRI‡‡ | ||||||||
| *Age in years. | |||||||||||
| †Days after onset at initiation of aciclovir. | |||||||||||
| ‡GCS score at initiation of aciclovir. | |||||||||||
| ¶Initial leucocyte cell count(/μl) (maximum values in serial CSF samples when the initial and maximum values were different). | |||||||||||
| §Initial CSF protein (mg/dl) (maximum values in serial CSF samples when the initial and maximum values were different); | |||||||||||
| ††Detection of lesion by initial computed tomography (CT): 0 = absent, 1 = present. | |||||||||||
| ‡‡Detection of lesion by initial magnetic resonance imaging (MRI): 0 = absent, 1 = present. ¶¶Detection of periodic lateralized epileptiform discharges (PLEDs) on electroencephalogram (EEG): 0 = absent, 1 = present. | |||||||||||
| **Corticosteroid administration: 0 = given, 1 = not given. | |||||||||||
| §§Outcome at 3 months after completion of aciclovir treatment. | |||||||||||
| GCS, Glasgow Coma Scale; CSF, cerebrospinal fluid. | |||||||||||
| 1 | M | 45 | 6 | 3 | 65 | 120 | 1 | 1 | 1 | 1 | Poor (death) |
| 2 | F | 57 | 7 | 3 | 377 (452) | 133 (358) | 1 | 1 | 1 | 1 | Poor (death) |
| 3 | M | 74 | 2 | 6 | 52 | 33 | 0 | 1 | 1 | 1 | Poor (moderate sequelae) |
| 4 | M | 34 | 4 | 14 | 148 | 36 | 0 | 1 | 1 | 0 | Good (complete recovery) |
| 5 | F | 60 | 7 | 3 | 4 (6) | 66 | 1 | 1 | 1 | 0 | Poor (severe sequelae) |
| 6 | M | 19 | 10 | 7 | 149 | 120 | 0 | 1 | 1 | 1 | Good (complete recovery) |
| 7 | F | 27 | 13 | 3 | 4 | 77 | 0 | 1 | 1 | 0 | Good (mild sequelae) |
| 8 | F | 21 | 11 | 6 | 22 | 92 | 1 | 0 | 1 | 0 | Good (mild sequelae) |
| 9 | M | 30 | 11 | 10 | 16 | 88 | 0 | 0 | 0 | 1 | Good (complete recovery) |
| 10 | F | 20 | 3 | 12 | 9 (12) | 33 | 0 | 0 | 0 | 1 | Good (mild sequelae) |
| 11 | F | 24 | 4 | 12 | 362 | 40 | 1 | 0 | 0 | 0 | Good (complete recovery) |
| 12 | F | 34 | 5 | 13 | 820 | 398 | 1 | 0 | 0 | 0 | Good (complete recovery) |
| 13 | M | 17 | 4 | 7 | 139 | 104 | 0 | 1 | 1 | 1 | Good (mild sequelae) |
| 14 | M | 57 | 7 | 3 | 944 | 410 | 1 | 1 | 1 | 0 | Poor (death) |
| 15 | F | 28 | 5 | 7 | 4 (6) | 77 | 0 | 1 | 1 | 1 | Good (mild sequelae) |
| 16 | M | 20 | 10 | 10 | 22 | 92 | 1 | 0 | 1 | 1 | Good (complete recovery) |
| 17 | M | 30 | 10 | 10 | 16 | 88 | 0 | 0 | 1 | 0 | Good (complete recovery) |
| 18 | F | 53 | 7 | 6 | 458 | 189 (235) | 1 | 1 | 1 | 1 | Poor (moderate sequelae) |
| 19 | F | 53 | 1 | 3 | 45 | 72 | 0 | 1 | 1 | 1 | Good (mild sequelae) |
| 20 | F | 34 | 5 | 6 | 22 | 68 | 1 | 1 | 1 | 0 | Good (complete recovery) |
| 21 | M | 34 | 3 | 13 | 22 | 86 | 1 | 1 | 1 | 0 | Good (mild sequelae) |
| 22 | M | 58 | 11 | 7 | 132 | 103 | 1 | 1 | 1 | 0 | Poor (severe sequelae) |
| 23 | M | 29 | 6 | 6 | 1376 | 240 | 0 | 1 | 1 | 0 | Good (complete recovery) |
| 24 | M | 76 | 12 | 3 | 102 | 305 | 1 | 1 | 1 | 0 | Poor (severe sequelae) |
| 25 | F | 33 | 9 | 12 | 61 | 61 | 1 | 0 | 0 | 1 | Good (complete recovery) |
| 26 | M | 58 | 6 | 3 | 24 | 56 | 1 | 1 | 1 | 1 | Poor (death) |
| 27 | M | 56 | 2 | 8 | 503 | 37 | 0 | 0 | 1 | 1 | Good (mild sequelae) |
| 28 | M | 77 | 1 | 12 | 571 | 580 | 0 | 0 | 1 | 0 | Good (mild sequelae) |
| 29 | F | 49 | 5 | 6 | 377 | 134 | 0 | 1 | 1 | 0 | Poor (moderate sequelae) |
| 30 | F | 77 | 3 | 3 | 7 (63) | 88 (104) | 0 | 1 | 1 | 0 | Poor (moderate sequelae) |
| 31 | F | 68 | 5 | 10 | 41 | 173 | 0 | 0 | 1 | 0 | Good (mild sequelae) |
| 32 | M | 38 | 7 | 10 | 4 (8) | 55 | 1 | 1 | 1 | 1 | Good (complete recovery) |
| 33 | M | 39 | 7 | 3 | 70 | 72 | 0 | 1 | 1 | 0 | Poor (moderate sequelae) |
| 34 | F | 71 | 1 | 3 | 422 | 90 | 0 | 0 | 1 | 1 | Good (mild sequelae) |
| 35 | F | 72 | 10 | 12 | 128 | 85 | 1 | 0 | 1 | 0 | Poor (severe sequelae) |
| 36 | M | 32 | 4 | 8 | 22 | 40 | 0 | 0 | 1 | 1 | Poor (moderate sequelae) |
| 37 | M | 71 | 10 | 12 | 18 | 39 | 0 | 1 | 1 | 1 | Good (mild sequelae) |
| 38 | F | 66 | 12 | 11 | 95 | 74 | 1 | 1 | 1 | 1 | Poor (severe sequelae) |
| 39 | M | 41 | 5 | 14 | 190 | 159 | 1 | 0 | 0 | 0 | Good (complete recovery) |
| 40 | F | 56 | 10 | 4 | 150 | 72 | 1 | 0 | 0 | 1 | Poor (death) |
| 41 | M | 27 | 4 | 13 | 21 (42) | 45 (86) | 1 | 1 | 1 | 0 | Good (complete recovery) |
| 42 | M | 66 | 5 | 3 | 56 | 85 | 1 | 1 | 1 | 0 | Poor (severe sequelae) |
| 43 | M | 45 | 12 | 8 | 4 (8) | 28 (42) | 0 | 0 | 1 | 0 | Good (complete recovery) |
| 44 | M | 47 | 6 | 3 | 15 (20) | 240 | 1 | 1 | 1 | 1 | Poor (moderate sequelae) |
| 45 | M | 45 | 10 | 3 | 60 | 84 | 0 | 1 | 1 | 0 | Poor (moderate sequelae) |