Table 3

 Psychometric properties for the physical and psychological MSIS-29 impact scales

Psychometric propertyMSIS-29 physicalMSIS-29 psychological
ICC, intraclass correlation coefficient; MSIS-29, Multiple Sclerosis Impact Scale.
Data quality
Item missing data0.5%0.1%
Computable scale scores93.5%98.4%
Item test–retest reliability (ICC)0.870.83
Scaling assumptions
Item mean scores range2.1 to 3.31.8 to 2.9
Item SD range1.0 to 1.51.1 to 1.4
Item skewness range−0.499 to +0.7420.201 to +1.235
Item-total correlation range0.55 to 0.850.41 to 0.86
Acceptability
Observed scale score range0 to 91.30 to 91.7
Scale score (mean (SD))43.9 (24.2)32.7 (23.2)
Floor/ceiling effect (%)4.7/1.61.6/1.6
Skewness−0.2310.459
Reliability
Cronbach’s α0.960.90
Scale test–retest reliability (ICC)0.870.83
Responsiveness
Correlation0.070.24
Effect size0.050.02
Clinically important difference:
    improved patients (n = 30)0.60.8
    deteriorated patients (n = 7)0.21.1