Anatomical region | BA | Coordinates† | F* | ||
---|---|---|---|---|---|
x | y | z | |||
Peak voxel localisation and significance of the brain regions characterised by the main effect of the onset age (EOAD v LOAD), of the ApoE genotype (E4 carriers, E4+, v non-carriers, E4−) and their interaction are shown. BA, Brodmann area. F, F value from the two way ANOVA leaving F1, 87 degrees of freedom after correcting for age. | |||||
*p<0.001, uncorrected for multiple comparisons. | |||||
†Coordinates from the atlas of Talairach and Tournoux.29 x is the distance in mm to the right (+) or left (−) of midline; y is the distance anterior (+) or posterior (−) to the anterior commissure, and z is the distance superior (+) or inferior (−) to a horizontal plane through the anterior and posterior commissures. | |||||
‡Voxels showing significant differences between EOAD (n = 27) and LOAD (n = 65) patients. | |||||
§Voxels showing significant differences between E4+ (n = 43) and E4− (n = 49) patients. | |||||
¶Voxels showing significant interactions between onset and ApoE groups. | |||||
(A) Main effect of onset age‡ | |||||
Inferior parietal | 40 | 61 | −29 | 35 | 18.68 |
lobule | −58 | −32 | 40 | 13.59 | |
Inferior temporal gyrus | 20 | −60 | −34 | −16 | 16.76 |
55 | −9 | −28 | 15.07 | ||
Orbitofrontal cortex | 11 | −7 | 52 | −20 | 13.78 |
4 | 58 | −22 | 10.26 | ||
Anterior cingulate | 32 | 5 | 21 | −8 | 12.69 |
gyrus | 24 | −4 | 31 | 16 | 10.15 |
Hippocampus | 28 | −34 | −4 | 13.96 | |
−16 | −16 | −8 | 10.52 | ||
(B) Main effect of ApoE genotype§ | |||||
Anterior cingulate | 24 | 4 | 45 | 12 | 10.96 |
cortex | 32 | −3 | 42 | 8 | 11.51 |
Medial frontal gyrus | 10 | 2 | 54 | 20 | 11.39 |
Basal frontal cortex | 11 | 4 | 34 | −24 | 9.92 |
−7 | 37 | −28 | 9.68 | ||
(C) Interaction¶ | |||||
Basal frontal cortex | 11 | −4 | 28 | −24 | 10.65 |
6 | 30 | −20 | 11.47 | ||
Hippocampus | 25 | −36 | −1 | 7.15 | |
−28 | −29 | −8 | 7.06 |