Table 3

SPM post hoc comparisons between EOAD and LOAD patients

Anatomical region	BA	Coordinates#			t*
Anatomical region	BA	x	y	z	t*
Peak voxel localisation and significance of the brain regions characterised by significant metabolic differences between EOAD (n = 27) and LOAD (n = 65) patients are shown. BA, Brodmann area. t, t value from post hoc t tests, leaving 90 degrees of freedom from 92 subjects and after correction for age.
#Coordinates from the atlas of Talairach and Tournoux.²⁹ x is the distance in mm to the right (+) or left (−) of midline; y is the distance anterior (+) or posterior (−) to the anterior commissure, and z is the distance superior (+) or inferior (−) to a horizontal plane through the anterior and posterior commissures.
*p<0.001, uncorrected for multiple comparisons.
(A) Reduced FDG uptake in EOAD as compared to LOAD patients
Orbitofrontal	11	−7	52	−20	3.71
gyrus		4	58	−22	3.20
Inferior parietal	40	53	−29	50	4.35
lobule		61	−29	35	4.32
		−58	−32	40	3.69
Inferior temporal	20	−60	−34	−16	4.09
gyrus		55	−9	−28	3.88
(B) Reduced FDG uptake in LOAD as compared to EOAD patients
Anterior cingulate	32	5	21	−8	3.56
gyrus	24	−4	31	16	3.19
Hippocampus		28	−34	−4	3.70
		−16	−16	−8	3.24