Areas where significant associations between brain activation differences (TD – SD) and APOE (presence versus absence of ε4) were detected (p<0.05 Bonferroni corrected) in the SPM analyses
| Talairach Coordinates | t Values (df = 18) | Cluster size (voxels) | Location (Brodmann’s area) | |||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| rCBF, relative cerebral blood flow. | ||||||
| Areas where ε4 carriers showed lower rCBF activation | 53 | 10 | −10 | 5.5 | 24 | Right superior temporal gyrus (38) |
| −53 | −36 | −27 | 5.3 | 20 | Left inferior temporal-fusiform gyrus (20) | |
| Areas where ε4 carriers showed higher rCBF activation | −42 | −56 | −4 | 5.6 | 12 | Left middle temporal gyrus (37) |
| 36 | −31 | 11 | 5.3 | 18 | Right transverse temporal gyrus (41) | |