Results from nine patients with idiopathic restless legs syndrome
| VAS | PLMW/h | |||||
|---|---|---|---|---|---|---|
| Mean (SEM) | Relative reduction of symptoms (%) | p Value (v baseline) | Mean (SEM) | Relative reduction of symptoms (%) | p Value (v baseline) | |
| Values are given as mean (SEM) and relative reduction of symptoms as compared with baseline. Visual analogue sale (VAS) and periodic leg movements per hour (PLMW/h) under the four conditions of baseline, apomorphine, apomorphine + naloxone, and apomorphine + metoclopramide. | ||||||
| Baseline | 5.8 (0.7) | – | – | 56.4 (19.2) | – | – |
| Apomorphine | 2.6 (0.8) | −54.5 | 0.011 | 1.1 (1.1) | −98.0 | 0.012 |
| Apomorphine + naloxone | 3.1 (0.8) | −46.4 | 0.015 | 0.9 (0.6) | −98.4 | 0.012 |
| Apomorphine + metoclopramide | 3.4 (0.8) | −41.7 | 0.028 | 14.2 (8.3) | −74.8 | 0.058 |