Regional cortical [11C]PMP k3 hydrolysis rates (mean (SD)) before and after 12 weeks of donepezil therapy in subjects with Alzheimer’s disease
| Rate of [11C]PMP k3 hydrolysis (per minute) | Pretreatment | Post-treatment | % Inhibition | Paired t test |
|---|---|---|---|---|
| Paired t test scores are presented with levels of significance. | ||||
| Mean cortical | 0.0210 (0.0019) | 0.0170 (0.0031) | 19.1 (9.4) | t = −7.9; p<0.0001 |
| Dorsolateral prefrontal | 0.0221 (0.0025) | 0.0172 (0.0025) | 22.2 (8.3) | t = −10.8; p<0.0001 |
| Parietal | 0.0203 (0.0019) | 0.0170 (0.0031) | 16.3 (9.9) | t = −6.6; p<0.0001 |
| Lateral temporal | 0.0199 (0.0022) | 0.0166 (0.0035) | 16.6 (14.1) | t = −4.4; p<0.001 |
| Anterior cingulate | 0.0231 (0.0023) | 0.0175 (0.0028) | 24.2 (6.9) | t = −14.1; p<0.0001 |
| Posterior cingulate | 0.0218 (0.0024) | 0.0170 (0.0031) | 22.6 (9.7) | t = −8.7; p<0.0001 |