Gpi DBS | STN DBS | |||||||
---|---|---|---|---|---|---|---|---|
Baseline | One year | Change* | p value† | Baseline | One year | Change* | p value† | |
Values are means (SD). | ||||||||
*“Change” refers to the mean (SD) of the individual changes in paired comparisons between the baseline and one year evaluations. Minus sign denotes reduction and plus sign increment. | ||||||||
†p value was calculated from paired comparisons between baseline and one year evaluations (Wilcoxon’s signed rank test). NS, not significant. | ||||||||
H and Y: Hoehn and Yahr Stage (1–5, from lesser to greater severity). | ||||||||
UPDRS: Unified Parkinson’s Disease Rating Scale; total score has a range 0–199, part II (ADL, activities of daily living) score 0–52, and part III (motor) score 0–108 (with higher levels indicating greater severity). | ||||||||
“Off” and “on” refer to medication effect (see Methods section). | ||||||||
Time spent in “off” state (UPDRS item 39): from 0 to 4 (1 = 1–25% of waking time; 2 = 26–50%; 3 = 51–75% and 4 = 76–100%). | ||||||||
Schwab and England scale: from 0 (maximal functional disability) to 100 (normal function). | ||||||||
CAPIT Dyskinesia Rating Scale: arithmetic mean of intensity (0–5) and duration (0–5). | ||||||||
l-dopa equivalent dose: see Methods. | ||||||||
No. of patients | 10 | 10 | ||||||
Sex (male/female) | 7/3 | 5/5 | ||||||
Age, years | 59.00 (7.23) | 62.00 (5.27) | ||||||
Duration of disease, years | 15.20 (4.19) | 14.80 (5.01) | ||||||
H and Y stage in “off” (No. ⩽3/>3) | 0/10 | 6/4 | 0/10 | 7/3 | ||||
UPDRS total score in “off” | 105.90 (24.06) | 65.20 (26.05) | −38% (19.64) | 0.005 | 99.20 (20.73) | 61.40 (23.49) | −38% (20.80) | 0.005 |
UPDRS II (ADL) score in “off” | 29.20 (6.44) | 20.10 (8.16) | −32% (18.80) | 0.007 | 29.10 (7.25) | 19.40 (7.06) | −33% (21.32) | 0.007 |
UPDRS III (motor) score in “off” | 63.40 (18.65) | 39.60 (15.69) | −35% (21.08) | 0.005 | 58.50 (13.44) | 35.00 (14.21) | −39% (20.72) | 0.005 |
UPDRS III (motor) score in “on” | 19.70 (11.40) | 17.50 (7.79) | +11% (67.73) | NS | 20.00 (9.44) | 21.90 (15.37) | +14% (70.05) | NS |
Time in “off”, UPDRS item 39 | 2.60 (0.70) | 1.30 (0.82) | −1.30 (0.82) | 0.006 | 2.30 (0.48) | 1.10 (0.32) | −1.20 (0.63) | 0.006 |
Schwab and England Scale in “off” | 30 (12.47) | 63 (17.67) | +33 (16.36) | 0.005 | 27 (14.18) | 69 (13.70) | +42 (15.49) | 0.005 |
CAPIT Dyskinesia Rating Scale | 3.00 (0.71) | 1.35 (0.82) | −56% (30.46) | 0.007 | 1.85 (0.97) | 1.05 (0.86) | −42% (51.28) | 0.034 |
l-dopa equivalent dose, mg/day | 762 (294) | 827 (337) | +9% (24.22) | NS | 1394 (500) | 1034 (451) | −24% (21.80) | 0.017 |