Table 3

 Multivariate life table analysis: RDNS sudden cardiac deaths (n = 21) v all other deaths + alive (n = 441)

Risk factorAdjusted for ECG 1†Adjusted for ECG 2†Adjusted for nephropathy stage
HR95% CIp ValueHR95% CIp ValueHR95% CIp Value
*Mean over time.
†ECG 1, ECG diagnostic of acute myocardial infarction or evolving diagnostic; ECG 2, ECG with left bundle branch block or electronically paced complexes.
Significant values in bold.
CASS, composite autonomic severity score; CI, confidence interval; FPG, fasting plasma glucose; Hb, haemoglobin; HDLC, high density lipoprotein cholesterol; HR, hazard ratio; JTc, corrected JT interval; QTc, corrected QT interval; RDNS, Rochester diabetic neuropathy study.
ECG 14.411.60 to 12.16 0.004 2.130.63 to 7.240.224
ECG 28.642.94 to 25.44 <0.001 5.301.35 to 20.77 0.017
ECG 1 or 24.251.35 to 13.41 0.014
JTc (ms)*1.010.99 to 1.020.5831.010.99 to 1.030.5151.000.97 to 1.020.840
QTc (ms)*1.021.00 to 1.03 0.019 1.021.01 to 1.04 0.008 1.010.99 to 1.040.244
FPG (10 mg/dl (0.56 mmol/l))*1.010.92 to 1.110.8031.010.92 to 1.110.7651.000.89 to 1.120.986
Glycosylated Hb (10%)*0.690.07 to 6.920.7500.510.05 to 5.350.5750.460.03 to 6.950.576
Calculated HbA1c (10%)*0.550.01 to 21.560.7500.340.01 to 14.320.5750.290.00 to 21.690.576
HDLC (10 mg/dl (0.26 mmol/l))*0.530.30 to 0.94 0.028 0.520.30 to 0.91 0.022 0.560.30 to 1.040.068
Cholesterol (10 mg/dl (0.26 mmol/l))*0.920.80 to 1.070.2750.920.80 to 1.060.2430.930.79 to 1.090.365
Triglycerides (10 mg/dl (0.11 mmol/l))*1.010.98 to 1.050.4851.020.98 to 1.050.3830.990.93 to 1.050.707
Creatinine (mg/dl)*1.911.34 to 2.73 <0.001 1.471.00 to 2.150.0511.650.88 to 3.080.117
Microalbuminuria (1000 mg/24 h)*2.181.33 to 3.57 0.002 2.371.47 to 3.80 <0.001 2.150.96 to 4.830.062
Total proteinuria (1000 mg/24 h)*1.651.19 to 2.28 0.003 1.681.21 to 2.34 0.002 1.220.73 to 2.030.439
Systolic blood pressure (10 mm Hg)*1.310.97 to 1.780.0801.310.97 to 1.790.0801.320.89 to 1.940.165
CASS total (points)1.471.18 to 1.83 <0.001 1.431.15 to 1.78 0.001 1.190.91 to 1.560.210
CASS adrenergic (points)2.051.26 to 3.33 0.004 1.921.20 to 3.06 0.006 1.270.65 to 2.470.481
CASS sudomotor (points)1.040.50 to 2.190.9110.900.42 to 1.900.7720.660.27 to 1.600.360
CASS cardiovagal (points)2.091.26 to 3.47 0.004 2.031.23 to 3.35 0.006 1.490.82 to 2.720.189
Nephropathy stage2.121.32 to 3.41 0.002 2.061.30 to 3.26 0.002
Neuropathy stage0.920.59 to 1.430.7170.910.59 to 1.400.6610.640.37 to 1.100.108