Table 2

Results of regression analyses predicting physical functioning variables from WMHs: unstandardised regression coefficients (B) and standardised coefficients (β) adjusted for age, sex, and depressive symptoms

WMH region	SF-12 physical component score	Purdue Pegboard (BH)	Purdue Pegboard (DH)	Purdue Pegboard (NDH)	Simple reaction time (msec)	Choice reaction time (msec)	Grip strength (kg)
Significant effects (p<0.01) are shown in bold.
BH, both hands; DH, dominant hand; NDH, non-dominant hand.
Frontal
B	−1.46	−0.22	−0.20	−0.22	0	4	−0.76
β	−0.17	−0.14	−0.10	−0.12	0.00	0.10	−0.07
p Value	<0.001	0.002	0.019	0.007	0.939	0.028	0.008
Temporal
B	−3.77	−0.72	−1.27	−1.14	14	21	−3.29
β	−0.10	−0.10	−0.15	−0.14	0.06	0.11	−0.07
p Value	0.023	0.022	0.001	0.002	0.160	0.017	0.008
Parietal
B	−1.72	−0.21	−0.15	−0.29	1	5	−0.97
β	−0.16	−0.11	−0.06	−0.13	0.01	0.10	−0.08
p Value	<0.001	0.017	0.159	0.004	0.826	0.037	0.007
Occipital
B	−0.24	−0.06	−0.01	−0.03	9	10	−0.61
β	−0.02	−0.03	−0.00	−0.01	0.13	0.18	−0.04
p Value	0.639	0.534	0.963	0.796	0.005	0.000	0.113
Cerebellum
B	−2.23	−1.47	−1.18	−0.67	0	16	3.96
β	−0.02	−0.07	−0.04	−0.03	0.01	0.03	0.03
p Value	0.662	0.129	0.306	0.546	0.858	0.54	0.293
Anterior horn
B	−0.08	−0.03	−0.04	−0.05	1	1	−0.16
β	−0.04	−0.08	−0.10	−0.12	0.07	0.12	−0.07
p Value	0.346	0.068	0.023	0.007	0.149	0.014	0.008
Posterior horn
B	0.00	−0.02	−0.04	−0.06	1	4	−0.22
β	0.00	−0.03	−0.04	−0.07	0.06	0.20	−0.05
p Value	0.983	0.450	0.359	0.105	0.179	<0.001	0.085
Periventricular body
B	−0.20	−0.02	−0.04	−0.05	1	2	−0.25
β	−0.07	−0.04	−0.06	−0.09	0.08	0.15	−0.08
p Value	0.102	0.362	0.172	0.045	0.080	0.002	0.005
Total brain white matter
B	−1.38	−0.21	−0.21	−0.29	3	8	−1.06
β	−0.14	−0.11	−0.09	−0.13	0.05	0.15	−0.09
p Value	0.003	0.015	0.040	0.003	0.299	0.001	0.002