Regional data for occipital cortex and basal ganglia
| Occipital | Caudate/putamen | Thalamus | Cerebellum | |
|---|---|---|---|---|
| Values are mean (SD) for regional variables in all patients. General linear model regression analysis for each variable (CBF, CBV, OEF, CMRo2, MTT) was undertaken to determine whether there was a significant increase or decrease in disease groups compared with the normal control group. As the age distribution was different between the groups, the “age” effect was included in the model. Bonferroni’s correction for multiple comparisons was applied for 45 contrasts for each variable and the level of significance was set at p<0.05. Statistical analysis was carried out after some preprocessing to justify the normality of the residuals, as stated in Methods. | ||||
| *p<0.05, **p<0.01 v normal controls. | ||||
| CBF, cerebral blood flow; CBV, cerebral blood volume; CMRo2, cerebral metabolic rate for oxygen; H, intracerebral haemorrhage group; MTT, mean transit time; normal, normal control; NS, non-symptomatic group; OEF, oxygen extraction fraction; PD, permanent deficit group; TIA, transient ischaemic attack without infarction group; TIA/I, transient ischaemic attack with infarction group. | ||||
| CBF (ml/min/100 g) | ||||
| Normal (n = 6) | 46.5 (10.7) | 43.9 (10.9) | 37.5 (6.5) | 47.8 (7.0) |
| NS (n = 7) | 47.4 (5.5) | 46.5 (8.7) | 43.2 (7.7) | 59.6 (8.9) |
| TIA (n = 12) | 43.3 (7.1) | 45.0 (6.5) | 42.6 (5.9) | 49.7 (6.4) |
| TIA/I (n = 16) | 36.3 (6.4)** | 36.2 (5.3) | 35.8 (4.4) | 55.9 (7.1) |
| PD (n = 10) | 38.3 (6.1) | 37.8 (5.6) | 36.6 (5.3) | 49.7 (6.0) |
| H (n = 12) | 40.6 (7.3) | 39.0 (9.0) | 35.6 (4.8) | 49.5 (7.1) |
| CBV (ml/100 g) | ||||
| Normal | 3.89 (0.23) | 3.13 (0.52) | 3.58 (0.74) | 4.09 (0.58) |
| NS | 4.94 (0.48) | 4.43 (1.01) | 4.53 (1.15) | 4.09 (0.15) |
| TIA | 6.12 (1.17) | 5.62 (1.72)** | 4.87 (1.12) | 4.12 (0.48) |
| TIA/I | 6.25 (1.83)* | 5.59 (1.66)** | 4.83 (1.47) | 4.12 (0.63) |
| PD | 5.25 (0.92) | 4.17 (0.65) | 4.57 (0.85) | 4.05 (0.64) |
| H | 4.36 (0.83) | 4.28 (0.99) | 4.29 (1.58) | 4.04 (0.64) |
| OEF (%) | ||||
| Normal | 43.8 (5.6) | 43.1 (4.5) | 39.3 (5.8) | 42.5 (6.3) |
| NS | 42.7 (4.8) | 43.0 (5.0) | 38.8 (5.3) | 38.1 (5.8) |
| TIA | 47.3 (6.4) | 46.3 (4.9) | 41.0 (5.6) | 41.5 (6.9) |
| TIA/I | 48.0 (5.2) | 49.1 (4.0) | 41.2 (6.6) | 42.3 (5.3) |
| PD | 40.7 (4.5) | 41.7 (3.5) | 34.9 (5.5) | 37.7 (4.5) |
| H | 44.2 (6.1) | 44.2 (5.6) | 37.0 (7.2) | 40.2 (6.9) |
| CMRo2 (ml/min/100 g) | ||||
| Normal | 3.84 (0.58) | 3.56 (0.52) | 2.82 (0.50) | 3.87 (0.51) |
| NS | 3.49 (0.18) | 3.38 (0.34) | 2.88 (0.43) | 3.83 (0.29) |
| TIA | 3.49 (0.57) | 3.51 (0.56) | 2.93 (0.56) | 3.85 (0.55) |
| TIA/I | 2.97 (0.40)** | 3.06 (0.35) | 2.53 (0.35) | 3.58 (0.39) |
| PD | 2.80 (0.59)** | 2.80 (0.54)* | 2.26 (0.49) | 3.31 (0.57) |
| H | 2.90 (0.31)** | 2.81 (0.47)* | 2.19 (0.27) | 3.19 (0.28) |
| MTT (s) | ||||
| Normal | 5.24 (1.18) | 4.48 (1.32) | 5.82 (1.42) | 5.23 (1.12) |
| NS | 6.32 (0.88) | 5.80 (1.18) | 6.39 (1.58) | 4.20 (0.70) |
| TIA | 8.68 (1.94) | 7.61 (2.33) | 6.95 (1.77) | 4.48 (0.68) |
| TIA/I | 10.6 (3.55)** | 9.26 (2.31)** | 8.15 (2.53) | 5.07 (1.16) |
| PD | 8.41 (2.08) | 6.82 (2.01) | 7.57 (1.53) | 4.89 (0.62) |
| H | 6.62 (1.64) | 6.75 (1.23) | 7.34 (2.86) | 5.02 (1.33) |