Diagnostic criteria for neuromyelitis optica
Diagnosis requires all absolute criteria and one major or two minor supportive criteria. |
Absolute criteria |
Optic neuritis |
Acute myelitis |
No evidence of clinical disease outside optic nerve or spinal cord |
Supportive criteria |
Major |
Negative brain MRI at onset |
Spinal MRI with signal abnormalities >3 vertebral segment lengths |
CSF pleocytosis >50 cells/mm3 or >5 neutrophils/mm3 |
Minor |
Bilateral optic neuritis |
Severe optic neuritis with visual acuity worse than 6/60 in at least |
one eye |
Severe, fixed, attack related weakness (MRC grade ⩽2) in one or |
more limbs |